Identification of Genes Related to Hair Follicle Cycle Development in Inner Mongolia Cashmere Goat by WGCNA

June 2022 in “ Frontiers in Veterinary Science ”

Guoyi Gong, Yixing Fan, Xiaochun Yan, Wenze Li, Xiaomin Yan, Hongfu Liu, Ludan Zhang, Ying Su, Jiaxin Zhang, Wei Jiang, Zhihong Liu, Zhiying Wang, Ruijun Wang, Yanjun Zhang, Qi Lv, Jinquan Li, Rui Su

hair follicle cycle secondary hair follicles Wnt signaling pathway Cell cycle WIF1 WNT11 BAMBI FZD10 NKD1 LEF1 CCND3 E2F3 CDC6 CDC25A hair follicle development hair growth cycle

TLDR Researchers found genes linked to hair growth cycles in Inner Mongolia cashmere goats, which could help understand and treat hair loss.

The study used Weighted Gene Co-expression Network Analysis (WGCNA) to analyze gene expression data from Inner Mongolia cashmere goats over 12 months, aiming to identify genes related to the periodic growth of secondary hair follicles. The research identified four modules significantly related to different stages of hair follicle development. The "steelblue" module, containing 348 genes, showed the strongest correlation with hair follicle cycle development. These genes were significantly enriched in 13 signal pathways, including the Wnt signaling pathway and Cell cycle, known to regulate hair follicle development. Ten key genes (WIF1, WNT11, BAMBI, FZD10, NKD1, LEF1, CCND3, E2F3, CDC6, and CDC25A) were validated, showing significant differences in expression across different months. This research provides valuable insights into the genetic basis of hair follicle development and could potentially inform future treatments for hair loss conditions.

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