Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing

May 2020 in “ Archiv für Tierzucht ”

Rui Su, Guoyi Gong, Lingtian Zhang, Xiaochun Yan, Fenghong Wang, Lei Zhang, Xuguang Qiao, Xiaokai Li, Jinquan Li

hair follicle growth cycle RNA sequencing differentially expressed genes anagen catagen telogen FGF5 FGFR1 RRAS MAPK signaling pathway hair growth cycle gene expression growth phase regression phase resting phase

TLDR Researchers identified genes that may affect hair growth in Cashmere goats.

In 2020, researchers conducted a study on Inner Mongolian Cashmere goats to identify key genes involved in the hair follicle growth cycle. Using RNA sequencing on skin samples from three 2-year-old female goats at different stages of the hair growth cycle, they found 51 differentially expressed genes (DEGs) between the anagen and catagen stages, 443 DEGs between catagen and telogen, and 779 DEGs between telogen and anagen. The most DEGs were found between the telogen and anagen stages. The study identified three genes - FGF5, FGFR1, and RRAS - that may impact hair follicle growth and development through the MAPK signaling pathway. These findings provided a basis for further research on hair growth and potential treatments for hair loss.

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research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

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research Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

46 citations , April 2019 in “Journal of Pineal Research”

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research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

14 citations , March 2019 in “Journal of Cosmetic Dermatology”

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research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations , October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

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11 citations , August 2018 in “Asian-Australasian journal of animal sciences”

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research Gene Expression and Localization of LAMTOR3 in the Skin Cells of Liaoning Cashmere Goats

4 citations , March 2018 in “Animal biotechnology”

The LAMTOR3 gene is involved in cashmere goat hair growth and is affected by certain treatments and other genes.

research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

14 citations , December 2016 in “PloS one”

Keratin 26 affects cashmere goat hair growth and is influenced by various treatments.

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66 citations , April 2016 in “Journal of Molecular Biology”

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations , April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

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277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

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8 / 8 results

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

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