Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing

    May 2020 in “ Archiv für Tierzucht ”
    Rui Su, Guoyi Gong, Lingtian Zhang, Xiaochun Yan, Fenghong Wang, Lei Zhang, Xuguang Qiao, Xiaokai Li, Jinquan Li
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    TLDR Researchers identified genes that may affect hair growth in Cashmere goats.
    In 2020, researchers conducted a study on Inner Mongolian Cashmere goats to identify key genes involved in the hair follicle growth cycle. Using RNA sequencing on skin samples from three 2-year-old female goats at different stages of the hair growth cycle, they found 51 differentially expressed genes (DEGs) between the anagen and catagen stages, 443 DEGs between catagen and telogen, and 779 DEGs between telogen and anagen. The most DEGs were found between the telogen and anagen stages. The study identified three genes - FGF5, FGFR1, and RRAS - that may impact hair follicle growth and development through the MAPK signaling pathway. These findings provided a basis for further research on hair growth and potential treatments for hair loss.
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