The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

The study from March 18, 2019, demonstrated that activated platelet-rich plasma (PRP) supernatant promotes hair growth by enhancing the expression of key growth factor receptors and activating signaling pathways in cultured human dermal papilla cells (DPCs). Specifically, the PRP supernatant increased the expression of phosphorylated FGFR1, PDGFRα, and PDGFRB, and activated the MAPK and Akt pathways, which are associated with cell proliferation. It also suggested involvement of the Wnt signaling pathway, indicated by decreased GSK-3 levels and increased β-catenin expression. These findings suggest that PRP could be a potential treatment for androgenic alopecia. The study's experiments were conducted with cells isolated from ten healthy volunteers, but the sample size for the assays was n = 3.