Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth

    August 2025 in “ Biomolecules ”
    Junchao Wang, Lusheng Wang, Shuang Gao, Xiaokun Li
    Studysummary This review explores the role of FGF signaling in hair follicle development and highlights its potential as a new therapeutic target for hair loss, which could surpass existing treatments in terms of efficacy and safety.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 113

    1. Serotonin Activates Dermal Papilla Cells and Promotes Hair Growth Scientific Reports · 2025
    2. Alopecia in Children with Cancer: A Review from Pathophysiology to Management American Journal of Clinical Dermatology · 2025
    3. Clinical and Trichoscopic Analysis of PRP Versus GFC for Male and Female Pattern Hair Loss Dermatologic Surgery · 2025
    4. Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases Stem Cell Reviews and Reports · 2025
    5. Revolutionary Approaches to Hair Regrowth: Follicle Neogenesis, Wnt/β-Catenin Signaling, and Emerging Therapies Cells · 2025
    6. Transcriptomics Sequencing Reveals Qu-Shi-Yu-Fa Decoction Promotes Hair Cycle And Keratinization By Upregulating FOXN1 And TGM3 To Treat Androgenetic Alopecia Phytomedicine · 2025
    7. Fgf21 Deficiency Delays Hair Follicle Cycling and Modulates miRNA–Target Gene Interactions in Mice Biology · 2025
    8. Platelet-Rich Plasma-Derived Exosomes Stimulate Hair Follicle Growth Through Activation of the Wnt/β-Catenin Signaling Pathway Regenerative Therapy · 2025
    9. Corticotropin-Releasing Hormone Inhibits Autophagy by Suppressing PTEN to Promote Apoptosis in Dermal Papilla Cells Annals of Medicine · 2025
    10. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    11. A Scoping Review of Exosome Delivery Applications in Hair Loss Cureus · 2025
    12. Exosome Revolution Or Marketing Mirage? AI-Based Multi-Domain Evaluation Of Claims, Scientific Evidence, Transparency, Public Sentiment, And Media Narratives Aesthetic Plastic Surgery · 2025
    13. Polynucleotides as a Novel Therapeutic Approach in Androgenetic Alopecia: An Analysis of Effectiveness and Safety Archives of Dermatological Research · 2025
    14. TMT-Based Quantitative Proteomics Reveals the Genetic Mechanisms of Secondary Hair Follicle Development in Fine-Wool Sheep PLoS ONE · 2025
    15. Anti-Androgenetic Effect of Diphlorethohydroxycarmalol on Testosterone-Induced Hair Loss by Inhibiting 5α-Reductase and Promoting Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells Toxicology in Vitro · 2025
    16. Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives Stem Cell Research & Therapy · 2025
    17. Pathogenesis and Regenerative Therapy in Vitiligo and Alopecia Areata: Focus on Hair Follicle Frontiers in Medicine · 2025
    18. Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice Journal of Ethnopharmacology · 2025
    19. Hair Regeneration Methods Using Cells Derived From Human Hair Follicles and Challenges to Overcome Cells · 2024
    20. FGF20 Secreted From Dermal Papilla Cells Regulates the Proliferation and Differentiation of Hair Follicle Stem Cells in Fine-Wool Sheep Journal of Animal Physiology and Animal Nutrition · 2024
    21. JAK-STAT1 as Therapeutic Target for EGFR Deficiency-Associated Inflammation and Scarring Alopecia EMBO Molecular Medicine · 2024
    22. Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza Sativa L. Cv. Buebang 3 CMU and Sanpatong Plants · 2024
    23. Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway International Journal of Molecular Sciences · 2024
    24. Synergistic Phytochemical and Pharmacological Actions of Hair Rise Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation Plants · 2024
    25. The Overexpression of R-Spondin 3 Affects Hair Morphogenesis and Development Along with the Formation and Maturation of Hair Follicle Stem Cells Frontiers in Physiology · 2024
    26. Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep Current Issues in Molecular Biology · 2024
    27. Assessing Low-Dose Oral Minoxidil Efficacy in Androgenetic Alopecia: A Comparative Study of AGA and AGA Unmasked by Telogen Effluvium Archives of Dermatological Research · 2024
    28. Shh Gene Regulates Proliferation and Apoptosis of Dermal Papilla Cells in Secondary Hair Follicle Growth Cycle of Cashmere Goats Animals · 2024
    29. Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2024
    30. Assessing the Efficacy of Mesotherapy Products: Ultra Exo Booster and Ultra S Line Plus in Hair Growth: An Ex Vivo Study Skin Research and Technology · 2024
    31. Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth Clinical Cosmetic and Investigational Dermatology · 2024
    32. Homocysteine in Androgenetic Alopecia: A Case Control Study and Observational Experiments on Mice Journal of Cosmetic Dermatology · 2024
    33. Genomic Characterization of Quality Wool Traits in Spanish Merino Sheep Genes · 2024
    34. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    35. The Development of Hair Follicles and Nail Developmental Biology · 2024
    36. Ellagic Acid Inhibits Dihydrotestosterone-Induced Ferroptosis and Promotes Hair Regeneration by Activating the Wnt/Beta-Catenin Signaling Pathway Journal of ethnopharmacology · 2024
    37. Necrosulfonamide Promotes Hair Growth and Ameliorates DHT-Induced Hair Growth Inhibition Journal of Dermatological Science · 2024
    38. Regulation of Hair Follicle Growth and Development by Different Alternative Spliceosomes of FGF5 in Rabbits Genes · 2024
    39. Acquired Curved Hair Is Caused by Fusion of Multiple Hair Matrix Cells Journal of Dermatological Science · 2024
    40. Exosomes for Hair Growth and Regeneration Journal of Bioscience and Bioengineering · 2023
    41. Status of Research on the Development and Regeneration of Hair Follicles International Journal of Medical Sciences · 2023
    42. Non-Invasive Assessment of Hair Regeneration in Androgenetic Alopecia Mice In Vivo Using Two-Photon and Second Harmonic Generation Imaging Biomedical Optics Express · 2023
    43. Recent Omics Advances In Hair Aging Biology And Hair Biomarkers Analysis Ageing Research Reviews · 2023
    44. Hair Follicle Transit-Amplifying Cells Phagocytose Dead Cells After Radiotherapeutic and Chemotherapeutic Injuries for Timely Regeneration Journal of Investigative Dermatology · 2023
    45. Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats' Follicle Development Assessed by Whole-Transcriptome Sequencing Technology Animals · 2023
    46. Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats Cells · 2023
    47. Novel Recombinant R-Spondin1 Promotes Hair Regeneration by Targeting the Wnt/β-Catenin Signaling Pathway Acta Biochimica et Biophysica Sinica · 2023
    48. Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action Current Issues in Molecular Biology · 2023
    49. Plasma Rich in Growth Factors as an Adjuvant Treatment for the Management of Frontal Fibrosing Alopecia: A Retrospective Observational Clinical Study Journal of Cutaneous Medicine and Surgery · 2023
    50. Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep Genes · 2023
    51. Androgenetic Alopecia: Therapy Update Drugs · 2023
    52. Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5 Journal of Animal Science and Biotechnology · 2023
    53. Effect of Plantago Asiatica L. Extract on the Anagen Phase in Human Hair Follicle Dermal Papilla Cells Journal of Cosmetic Dermatology · 2023
    54. Hair Follicle Development and Cashmere Traits in Albas Goat Kids Animals · 2023
    55. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 Cells · 2023
    56. Co-Expression Pattern of VEGFR-2 With Indicators Related to Proliferation, Apoptosis, and Differentiation of Anagen Hair Follicles Open Life Sciences · 2023
    57. Regulation of Stem Cell Fate by HSPGs: Implication in Hair Follicle Cycling npj Regenerative Medicine · 2022
    58. Novel PLCL Nanofibrous/Keratin Hydrogel Bilayer Wound Dressing for Skin Wound Repair Colloids and Surfaces B: Biointerfaces · 2022
    59. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    60. Gender Difference in Hair Length Revealed by CRISPR-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations International Journal of Molecular Sciences · 2022
    61. Impacts of Manipulating Cell Sorting on In Vitro Hair Follicle Regeneration Journal of Bioscience and Bioengineering · 2022
    62. Modeling of Ionizing Radiation Induced Hair Follicle Regenerative Dynamics Journal of Theoretical Biology · 2022
    63. Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12) International Journal of Molecular Sciences · 2022
    64. Role of the Soluble Epoxide Hydrolase in Hair Follicle Stem Cell Homeostasis and Hair Growth Pflügers Archiv - European Journal of Physiology · 2022
    65. The Stem Cell Quiescence and Niche Signaling Is Disturbed in the Hair Follicle of the Hairpoor Mouse, an MUHH Model Mouse Stem cell research & therapy · 2022
    66. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    67. MiR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit Genes · 2022
    68. Safflower Oil Body Nanoparticles Deliver hFGF10 to Hair Follicles and Reduce Microinflammation to Accelerate Hair Regeneration in Androgenetic Alopecia International Journal of Pharmaceutics · 2022
    69. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022
    70. Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice Frontiers in Pharmacology · 2021
    71. Recreation of a Hair Follicle Regenerative Microenvironment: Successes and Pitfalls Bioengineering & translational medicine · 2021
    72. Androgenetic Alopecia and COVID-19: A Review of the Hypothetical Role of Androgens Dermatologic Therapy · 2021
    73. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    74. Side Effects of Low-Dose Oral Minoxidil for Treating Alopecia Journal of The American Academy of Dermatology · 2021
    75. Adverse Effects of Low-Dose Oral Minoxidil for Androgenetic Alopecia in 435 Patients Journal of The American Academy of Dermatology · 2020
    76. Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells Frontiers in Cell and Developmental Biology · 2020
    77. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    78. Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals Journal of The American Academy of Dermatology · 2020
    79. Androgenetic Alopecia in COVID-19: Comparison to Age-Matched Epidemiologic Studies and Hospital Outcomes With or Without the Gabrin Sign Journal of The American Academy of Dermatology · 2020
    80. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    81. Effect of Nutritional Restriction on the Hair Follicles Development and Skin Transcriptome of Chinese Merino Sheep Animals · 2020
    82. Analysis of lncRNAs Expression Profiles in Hair Follicles of Hu Sheep Lambskin Animals · 2020
    83. Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep Cell Death and Disease · 2020
    84. Androgenetic Alopecia Present in the Majority of Patients Hospitalized with COVID-19: The 'Gabrin Sign' Journal of The American Academy of Dermatology · 2020
    85. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    86. Efficacy of Intralesional and Oral Dutasteride in the Treatment of Androgenetic Alopecia: A Systematic Review Skin appendage disorders · 2020
    87. Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature Skin appendage disorders · 2020
    88. Hair Eruption Initiates and Commensal Skin Microbiota Aggravate Adverse Events of Anti-EGFR Therapy Science Translational Medicine · 2019
    89. Optimal Stimulation Toward the Dermal Papilla Lineage Can Be Promoted by Combined Use of Osteogenic and Adipogenic Inducers FEBS open bio · 2019
    90. An Osteopontin-Derived Peptide Inhibits Human Hair Growth by Decreasing Fibroblast Growth Factor-7 Production in Outer Root Sheath Keratinocytes British Journal of Dermatology · 2019
    91. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    92. Bioinformatics Analysis of Evolutionary Characteristics and Biochemical Structure of FGF5 Gene in Sheep Gene · 2019
    93. Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis Journal of Pineal Research · 2019
    94. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    95. Oil Body Bound Oleosin-rhFGF9 Fusion Protein Expressed in Safflower Stimulates Hair Growth and Wound Healing in Mice BMC Biotechnology · 2018
    96. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    97. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    98. Stimulation of Mouse Vibrissal Follicle Growth by Recombinant Human Fibroblast Growth Factor 20 Biotechnology Letters · 2018
    99. Hair Growth Is Promoted by BeauTop via Expression of EGF and FGF-7 Molecular Medicine Reports · 2018
    100. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    101. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    102. Intradermal Injections of a Hair Growth Factor Formulation for Enhancement of Human Hair Regrowth: Safety and Efficacy Evaluation in a First-in-Man Pilot Clinical Study Journal of Cosmetic and Laser Therapy · 2018
    103. Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss Journal of Cosmetic and Laser Therapy · 2018
    104. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    105. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    106. VEGF165 Induces Differentiation of Hair Follicle Stem Cells Into Endothelial Cells and Plays a Role in In Vivo Angiogenesis Journal of Cellular and Molecular Medicine · 2017
    107. Analysis of the FGF Gene Family Provides Insights into Aquatic Adaptation in Cetaceans Scientific reports · 2017
    108. Enhanced Effect of Fibroblast Growth Factor-2-Containing Dalteparin/Protamine Nanoparticles on Hair Growth Clinical, cosmetic and investigational dermatology · 2016
    109. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    110. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    111. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    112. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    113. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012

    Related research 5

    1. What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured: A Review Applied Sciences · 2020
    2. Treatments of Hereditary Hair Loss (Alopecia) 2018
    3. Blockade of S100A3 Activity Inhibits Murine Hair Growth Genetics and Molecular Research · 2015
    4. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    5. Treatment of Hair Loss The New England Journal of Medicine · 1999