Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice

    January 2025 in “ Journal of Ethnopharmacology
    Huanzhu Qian, Zhen Ye, Yu Hu, Liulin Chen, Linzhen Li, Kaihua Qin, Qiaobo Ye, Xiaohong Zuo
    TLDR Dahuang-Gancao Decoction improves hair growth in androgenetic alopecia.
    The study explores the effects of Dahuang-Gancao Decoction (DGD) on androgenetic alopecia (AGA) in a testosterone-induced mouse model, involving 12 mice per group. DGD, a traditional Chinese medicine, was found to significantly improve hair growth by promoting hair follicle stem cell proliferation and activating the Wnt/β-catenin signaling pathway. Both oral and topical applications of DGD were effective, with topical application showing particular promise by enhancing hair follicle regeneration and avoiding adverse reactions associated with oral use. The study suggests DGD as a potential alternative treatment for AGA, comparable to minoxidil, with key active ingredients like catechin and isoliquiritigenin contributing to its efficacy.
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