Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

    February 2022 in “ Journal of Dermatological Treatment
    Linlin Bao, Haifeng Zong, Sining Fang, Lixiong Zheng, Yuan-Hong Li
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    TLDR Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.
    This study evaluated the efficacy of electrodynamic microneedling combined with 5% minoxidil in treating androgenetic alopecia (AGA) in Chinese male patients and explored the underlying mechanisms. The study involved 71 male volunteers with AGA who completed the entire trial and follow-up. The combination therapy showed superior therapeutic effects clinically, with further upregulation of FZD3, ß-catenin, and LEF-1 expression levels at both mRNA and protein levels in the treated areas. The study concluded that microneedling combined with 5% minoxidil can improve AGA, and the underlying mechanism may involve activation of the Wnt/ß-catenin signaling pathway.
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