Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

This study evaluated the efficacy of electrodynamic microneedling combined with 5% minoxidil in treating androgenetic alopecia (AGA) in Chinese male patients and explored the underlying mechanisms. The study involved 71 male volunteers with AGA who completed the entire trial and follow-up. The combination therapy showed superior therapeutic effects clinically, with further upregulation of FZD3, ß-catenin, and LEF-1 expression levels at both mRNA and protein levels in the treated areas. The study concluded that microneedling combined with 5% minoxidil can improve AGA, and the underlying mechanism may involve activation of the Wnt/ß-catenin signaling pathway.