Alopecia Areata Multiplex Following Autologous Dermal Micrograft Injection for Treatment of Androgenetic Alopecia

A case study has been reported where a 45-year-old man with androgenetic alopecia (AGA) underwent an autologous dermal micro-graft for AGA and developed alopecia areata (AA) four weeks after the procedure. The AA gradually spread to other areas, including the eyebrow and beard. Immunohistochemical analysis demonstrated T-cell infiltration, as well as MHC class I antigen expression, revealing the typical findings of spontaneous AA. These observations suggest that the release of antigen/epitopes from the hairs in the donor site may have triggered the loss of immune privilege in the injection site, resulting in an autoimmune lymphocyte attack against HFs, resembling AA.