Alopecia Areata Multiplex Following Autologous Dermal Micrograft Injection for Treatment of Androgenetic Alopecia

    May 2019 in “ Journal of The European Academy of Dermatology and Venereology ”
    Shinobu Toshima, Yoshimasa Kurihara, Enge Wang, Hideko Nomura, Y. Hayashi, Angela M. Christiano, Masayuki Amagai, Noriko Umegaki-Arao
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    TLDR Hair loss treatment caused more hair loss in a man.
    A case study has been reported where a 45-year-old man with androgenetic alopecia (AGA) underwent an autologous dermal micro-graft for AGA and developed alopecia areata (AA) four weeks after the procedure. The AA gradually spread to other areas, including the eyebrow and beard. Immunohistochemical analysis demonstrated T-cell infiltration, as well as MHC class I antigen expression, revealing the typical findings of spontaneous AA. These observations suggest that the release of antigen/epitopes from the hairs in the donor site may have triggered the loss of immune privilege in the injection site, resulting in an autoimmune lymphocyte attack against HFs, resembling AA.
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