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Glossary Immune Privilege

certain body areas limit immune responses to prevent tissue damage

Immune privilege refers to certain areas of the body, such as the eyes, brain, and hair follicles, where the immune system's activity is naturally limited to prevent damage to delicate tissues. This means that these areas can tolerate the introduction of antigens without eliciting a strong inflammatory immune response, which helps protect critical functions but can also make them vulnerable to infections or diseases.

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Research

5 / 1000+ results

research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

253 citations , December 2007 in “Journal of Investigative Dermatology”

This study suggests that human hair follicles may actively suppress natural killer cells, which contrasts with the observed defects in NK cell regulation in alopecia areata.

research Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

139 citations , October 2005 in “Journal of Investigative Dermatology”

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

research Hair follicle immune privilege and its collapse in alopecia areata

134 citations , July 2020 in “Experimental dermatology”

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

102 citations , December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This review discusses the role of immune privilege collapse in the pathogenesis of alopecia areata, emphasizing the potential for therapeutic manipulation of hair bulb immune privilege to offer new treatment options, and reports no new results.

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community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Duoxidil, Dutasteride and oral Minoxidil

in Minoxidil 89 upvotes 11 months ago

The conversation discusses hair regrowth treatments, specifically using a combination of oral and topical minoxidil, oral and topical dutasteride, and PRP. There is skepticism about the authenticity of the results, with some users questioning the changes in hair and skin appearance.

community Holding out for a miracle drug

59 upvotes 4 months ago

A 41-year-old male has been using a combination of treatments for hair regrowth, including finasteride, minoxidil, a laser cap, ketoconazole shampoo, and rosemary oil, with some progress noted. He is maintaining his current regimen in hopes of a future miracle drug while considering hair transplants and other treatments like dutasteride and copper peptides.

community 5 years post hair transplant, 3 months on minoxidil only

326 upvotes 9 months ago

The user had a hair transplant five years ago and started using minoxidil three months ago. Commenters recommend adding finasteride or other DHT blockers to prevent further hair loss and maintain results.

community Balding Sucks. Balding Young is Awful. Balding Young and being Unable to Grow any Facial Hair is Hell on Earth

in Update 339 upvotes 1 year ago

A 25-year-old is frustrated with hair loss and inability to grow facial hair despite using oral finasteride and minoxidil for over a year. Suggestions include trying topical treatments, considering a hair system, or seeking professional help for mental health.

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