Assessment of Tissue Levels of Dickkopf-1 in Androgenetic Alopecia and Alopecia Areata

    July 2015 in “ Journal of Cosmetic Dermatology ”
    Marwa M Fawzi, Sara H. Mahmoud, Olfat G. Shaker, Marwah A. Saleh
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    TLDR Higher DKK-1 levels found in hair loss patients; L-ascorbic acid 2-phosphate, L-threonate, and ginsenoside F2 may help promote hair growth.
    This study found that tissue levels of DKK-1 were significantly higher in patients with androgenetic alopecia (AGA) and alopecia areata (AA) compared to controls. DKK-1 was higher in male patients with AGA than in female patients with AGA and was negatively correlated with disease duration in AGA. The study suggests that DKK-1 may play a role in the pathogenesis of AGA and AA and may be a promising therapeutic target for these hair diseases. Additionally, the study found that L-ascorbic acid 2-phosphate and L-threonate inhibited DHT-induced DKK-1 expression in cultured hDP cells, and ginsenoside F2 may be a potential new therapeutic option for hair growth promotion.
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