Emerging Treatments in Alopecia

November 2014 in “ Expert Opinion on Emerging Drugs ”

Leyre Falto-Aizpurua, Sonal Choudhary, Antonella Tosti

TLDR New alopecia treatments aim for better results and fewer side effects.

The document from 2014 discusses current and emerging treatments for different types of alopecia, including androgenetic alopecia, alopecia areata, chemotherapy-induced alopecia, trichotillomania, and scarring alopecia. The emerging treatments include stem cells, growth factors, cellular pathways, and robotic hair transplant. The document also mentions ongoing clinical trials for various treatments, such as platelet-rich plasma, minoxidil, IL-2, abatacept, ruxolitinib, and inositol. The authors suggest that new effective treatments with fewer side effects are needed to enhance patient compliance.

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research A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

50 citations , October 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.

research Microrefined Microfollicular Hair Transplant

3 citations , September 2014 in “Annals of plastic surgery”

The new hair transplant method improves results and reduces surgery time.

research Evaluation and Diagnosis of the Hair Loss Patient

69 citations , September 2014 in “Journal of The American Academy of Dermatology”

Trichoscopy is a quick, cost-effective tool for diagnosing different hair loss conditions.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations , June 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

research Vitamin D Deficiency in Alopecia Areata

105 citations , June 2014 in “British journal of dermatology/British journal of dermatology, Supplement”

research Topical Valproic Acid Increases Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

37 citations , April 2014 in “Journal of Dermatology”

Valproic acid increases hair count in men with hair loss.

research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

57 citations , March 2014 in “Experimental Dermatology”

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

research Potential Relationship Between the Canonical Wnt Signaling Pathway and Expression of the Vitamin D Receptor in Alopecia

21 citations , March 2014 in “Clinical and experimental dermatology”

Targeting the Wnt pathway might help treat hair loss.

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , March 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Micropigmentation: Camouflaging Scalp Alopecia and Scars in Korean Patients

26 citations , February 2014 in “Aesthetic Plastic Surgery”

Micropigmentation safely and effectively hides scalp hair loss and scars.

research Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

99 citations , January 2014 in “Nature communications”

Scientists created stem cells that can grow hair and skin.

research Follicular Unit Extraction Hair Transplant Harvest: A Review of Current Recommendations and Future Considerations

16 citations , January 2014 in “Dermatology online journal”

The document concludes that Follicular Unit Extraction is an advanced, less invasive hair transplant method with fewer side effects than traditional methods.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

20 citations , January 2014 in “Anti-Cancer Drugs”

PTH-CBD could help prevent and treat hair loss caused by chemotherapy in mice.

research Promotional Effect of Platelet-Rich Plasma on Hair Follicle Reconstitution In Vivo

63 citations , December 2013 in “Dermatologic Surgery”

Platelet-Rich Plasma (PRP) increases the number of new hair follicles and speeds up hair formation.

research Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

33 citations , November 2013 in “Journal of The American Academy of Dermatology”

Pioglitazone usually doesn't effectively treat or cure lichen planopilaris.

research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

48 citations , October 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Efficacy and Tolerability of Two Scalp Cooling Systems for the Prevention of Alopecia Associated with Docetaxel Treatment

52 citations , May 2013 in “Supportive Care in Cancer”

Scalp cooling significantly reduces hair loss in chemotherapy patients.

research New Investigational Drugs for Androgenetic Alopecia

48 citations , April 2013 in “Expert Opinion on Investigational Drugs”

Possible new treatments for common hair loss include drugs, stem cells, and improved transplants.

research Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44

68 citations , April 2013 in “Journal of Investigative Dermatology”

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

research Reduced Level of 25-Hydroxyvitamin D in Chronic/Relapsing Alopecia Areata

40 citations , April 2013 in “Dermato-endocrinology”

People with chronic Alopecia Areata often have lower vitamin D levels.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin A affects hair loss and immune response in alopecia areata.

research Retinoids Putting the 'A' in Alopecia

7 citations , February 2013 in “Journal of Investigative Dermatology”

Vitamin A may influence hair loss conditions like alopecia, but more research is needed to understand how.

research Iron Plays a Certain Role in Patterned Hair Loss

40 citations , January 2013 in “Journal of Korean Medical Science”

Iron deficiency may contribute to hair loss.

research Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

41 citations , January 2013 in “Stem Cells and Development”

Low-dose UVB light improves hair growth effects of certain stem cells by increasing reactive oxygen species.

research Serum Ferritin and Vitamin D in Female Hair Loss: Do They Play a Role?

62 citations , January 2013 in “Skin Pharmacology and Physiology”

Low iron and vitamin D levels are linked to hair loss in women.

research The Prostamide-Related Glaucoma Therapy, Bimatoprost, Offers a Novel Approach for Treating Scalp Alopecias

53 citations , October 2012 in “The FASEB Journal”

Bimatoprost, a glaucoma medication, may also help treat hair loss.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

research Hair Organ Regeneration Via Bioengineered Hair Follicular Unit Transplantation

66 citations , May 2012 in “Scientific Reports”

Scientists successfully created and transplanted bioengineered hair follicles that function like natural ones, suggesting a new treatment for hair loss.

research Treatment Options for Alopecia: An Update, Looking to the Future

35 citations , May 2012 in “Expert Opinion on Pharmacotherapy”

The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

research Endogenous Retinoids in the Hair Follicle and Sebaceous Gland

50 citations , January 2012 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research A Study to Evaluate the Efficacy of Various Topical Treatment Modalities for Alopecia Areata

20 citations , January 2012 in “International journal of trichology”

Steroids are the best treatment for Alopecia Areata with few side effects.

research Therapeutic Hotline: Effectiveness of the Association of Cetirizine and Topical Steroids in Lichen Planus Pilaris - An Open-Label Clinical Trial

9 citations , September 2010 in “Dermatologic therapy”

Combining cetirizine and topical steroids can effectively manage severe lichen planus pilaris.

research Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

105 citations , December 2009 in “Archives of dermatology”

A specific drug can help treat Lichen Planopilaris, a condition causing permanent hair loss.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss

43 citations , January 2007 in “American Journal of Clinical Dermatology”

Combined minoxidil and tretinoin solution works as well as regular minoxidil for male hair loss.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , November 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells

92 citations , December 2005 in “The Journal of clinical investigation/The journal of clinical investigation”

Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations , October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

8 / 8 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , November 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata

5 citations , January 2022 in “Dermatology Reports”

Tofacitinib treatment for hair loss may worsen acne.

research Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata

October 2021 in “Dermatology Reports”

Tofacitinib, a hair regrowth treatment, may worsen acne.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

4 citations , July 2018 in “PubMed”

Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.

research Emerging Treatments in Alopecia

47 citations , November 2014 in “Expert Opinion on Emerging Drugs”

New alopecia treatments aim for better results and fewer side effects.

research Noninflammatory, Nonpruritic Alopecia of Horses

5 citations , December 2013 in “Veterinary Clinics of North America: Equine Practice”

Some horses lose hair without inflammation or itching due to various conditions, and while mainly a cosmetic issue, diagnosis requires examination and biopsies, and breeding is not advised if it's hereditary.

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

109 citations , May 2011 in “Dermatologic Therapy”

Alopecia areata is a type of hair loss that can lead to complete baldness, often associated with other autoimmune conditions, and half of the cases may see hair return within a year.