A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

August 2013 in “ British Journal of Dermatology ”

Anna Trink, Elisabetta Sorbellini, Paola Bezzola, Luigi Fabrizio Rodella, Rita Rezzani, Yuval Ramot, Francesca Rinaldi

TLDR Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

A decade ago, a study was conducted on 45 patients with alopecia areata (AA), an autoimmune condition causing hair loss. The patients were treated with platelet-rich plasma (PRP), triamcinolone acetonide (TrA), or a placebo. The results showed that PRP significantly increased hair regrowth, decreased hair dystrophy and burning/itching sensation, and raised Ki-67 levels, a marker for cell proliferation, compared to TrA or placebo. No side effects were reported during the treatment. The study concluded that PRP could be a safe and effective treatment option for AA, potentially a better alternative to TrA. However, the researchers emphasized the need for further controlled and randomized studies to confirm these findings in a larger patient group.

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research Commentary on Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

13 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma (PRP) may help promote hair growth and improve graft survival after hair transplantation, but more research is needed to confirm its effectiveness and determine the best dosage.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , December 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

research Topical and Intralesional Therapies for Alopecia Areata

36 citations , May 2011 in “Dermatologic therapy”

No treatments fully cure or prevent alopecia areata; some help but have side effects or need more research.

research Investigative Guidelines for Alopecia Areata

66 citations , May 2011 in “Dermatologic therapy”

Guidelines help design better trials to compare alopecia areata treatments.

research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research Alopecia Areata Update

391 citations , February 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , November 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Guidelines for the Management of Alopecia Areata

182 citations , October 2003 in “British Journal of Dermatology”

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

research Clinical Presentations of Alopecia Areata

13 citations , December 2001 in “Dermatologic therapy”

Alopecia areata causes varying hair loss patterns, affecting hair, nails, and possibly glands, with treatment outcomes depending on disease duration and extent.

6 / 6 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , November 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Sensitive Scalp: An Epidemiologic Study in Patients with Hair Loss

1 citations , January 2022 in “Dermatology Reports”

Many people with hair loss, especially those with telogen effluvium and alopecia areata, often have a sensitive scalp.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Intralesional Platelet-Rich Plasma vs. Intralesional Triamcinolone in the Treatment of Alopecia Areata: A Comparative Study

15 citations , January 2015 in “International journal of medical research and health sciences”

Platelet rich plasma is as effective as triamcinolone for treating alopecia areata.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Hair Loss in Children: Common and Uncommon Causes; Clinical and Epidemiological Study in Jordan

30 citations , January 2013 in “International Journal of Trichology”

The most common causes of hair loss in Jordanian children are fungal infections, autoimmune hair loss, and hair shedding after fever, with zinc deficiency also being a notable cause.