Commentary on Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

In 2012, the potential of autologous platelet-rich plasma (PRP) as a therapeutic tool for promoting hair growth was explored. PRP, known for its role in wound healing, was found to upregulate levels of type I collagen, matrix metalloproteinase (MMP)-1, and MMP-2, and increase the expression of G1 cell cycle regulators. A study by Uebel in 2006 showed 15% better graft survival in 20 male patients whose grafts were stored in PRP before implantation. However, the study had limitations and was not blinded or interpreted by independent researchers. The commentary also highlighted that PRP-treated dermal papilla cells had a higher rate of proliferation and showed more rapid hair growth in mice. However, the exact concentration and dosing parameters of PRP were still unknown, and the time and cost of equipment setup were obstacles to its widespread implementation in hair transplantation. The commentary concluded that while PRP has been proven to improve wound healing, more studies were needed to confirm its effectiveness in promoting hair growth and improving follicle survival after transplantation.