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    Glossary Matrix Metalloproteinase-2

    enzyme that breaks down proteins in the extracellular matrix

    Matrix Metalloproteinase-2 (MMP-2), also known as Gelatinase A, is an enzyme that breaks down proteins in the extracellular matrix, particularly type IV collagen. This process is crucial for tissue remodeling, wound healing, and angiogenesis, but excessive MMP-2 activity can contribute to diseases like cancer and fibrosis by promoting abnormal tissue degradation.

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    1. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle Experimental and Therapeutic Medicine · 2016 · 21 citations
    2. A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women Fertility and Sterility · 2005 · 8 citations
    3. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    4. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    5. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    6. Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2 Journal of Neuroinflammation · 2018 · 22 citations
    7. In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Indonesian Journal of Science and Technology · 2022 · 7 citations
    8. 1396 Interferon-24 regulates the expression of MMP1 and dermal collagen of the skin Journal of Investigative Dermatology · 2023
    9. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    10. Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice International Journal of Molecular Sciences · 2025
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