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    Glossary Matrix Metalloproteinase-2

    enzyme that breaks down proteins in the extracellular matrix

    Matrix Metalloproteinase-2 (MMP-2), also known as Gelatinase A, is an enzyme that breaks down proteins in the extracellular matrix, particularly type IV collagen. This process is crucial for tissue remodeling, wound healing, and angiogenesis, but excessive MMP-2 activity can contribute to diseases like cancer and fibrosis by promoting abnormal tissue degradation.

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    1. Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle Experimental and Therapeutic Medicine · 2016 · 21 citations
    2. A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women Fertility and Sterility · 2005 · 8 citations
    3. Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation Journal of Investigative Dermatology · 2003 · 56 citations
    4. Matrix Metalloproteinase-9 Is Involved in the Regulation of Hair Canal Formation 2010 · 20 citations
    5. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    6. Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2 Journal of Neuroinflammation · 2018 · 22 citations
    7. In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition Indonesian Journal of Science and Technology · 2022 · 7 citations
    8. 1396 Interferon-24 regulates the expression of MMP1 and dermal collagen of the skin Journal of Investigative Dermatology · 2023
    9. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    10. Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice International Journal of Molecular Sciences · 2025
    11. MON-203 Dermatological Effects Of Hormone Replacement Therapy Journal of the Endocrine Society · 2025
    12. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    13. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018 · 57 citations
    14. 250 Sweat glands shrink upward with aging, causing dermal layer defects that lead to loss of skin elasticity and wrinkling-establishment of 3D imaging method for skin appendages Journal of Investigative Dermatology · 2017
    15. Thymosin β<sub>4</sub>increases hair growth by activation of hair follicle stem cells The FASEB Journal · 2003 · 98 citations
    16. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    17. 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α American Journal Of Pathology · 2010 · 38 citations
    18. Collagenase IV plays an important role in regulating hair cycle by inducing VEGF, IGF-1, and&nbsp;TGF-&beta; expression Drug Design Development and Therapy · 2015 · 27 citations
    19. Commentary on Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012 · 13 citations
    20. Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model European journal of pharmacology · 2015 · 10 citations
    21. The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β- Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells Research Square (Research Square) · 2024
    22. Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp Journal of dermatological science · 2012 · 4 citations
    23. Anti-aging effect of <i>Grateloupia elata</i> extract in skin Journal of Applied Biological Chemistry · 2025
    24. 879 IL-9 mediated human primary keratinocytes invasion is dependent on MLC controlled contractility and independent of MMP activity Journal of Investigative Dermatology · 2018
    25. Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells Proceedings of the National Academy of Sciences of the United States of America · 2017 · 92 citations
    26. Desmodesmus pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing Life · 2024 · 1 citations
    27. Skin, Genetic Defects, and Aging SpringerBriefs in bioengineering · 2016
    28. Scarless wound healing: Transitioning from fetal research to regenerative healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018 · 79 citations
    29. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway International Journal of Biological Sciences · 2023 · 9 citations
    30. In Vivo Evaluation of<i>Eclipta alba</i>Extract as Anticancer and Multidrug Resistance Reversal Agent Nutrition and Cancer · 2014 · 9 citations