The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β-Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells

    November 2024 in “ Research Square (Research Square) ”
    BoYoon Chang, Yuri Hwang, In Ah Kim … Sung‐Yeon Kim

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study reported that Moracin M, a compound from the Moraceae family, significantly promoted hair growth and vascular regeneration by enhancing cell proliferation and Wnt signaling activation in laboratory settings, suggesting it may offer a promising alternative to existing hair growth treatments like minoxidil.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. Topical Minoxidil Overdose in a Young Man With Androgenetic Alopecia: A Case Report Curēus · 2024
    2. Identification of an Osteopontin-Derived Peptide That Binds Neuropilin-1 and Activates Vascular Repair Responses and Angiogenesis Pharmacological Research · 2024
    3. Comparison of Efficacy of Autologous Platelet Rich Plasma Therapy With 5% Topical Minoxidil Spray in Treating Alopecia Areata: A Head-to-Head Assessment of Novel Approaches Cureus · 2024
    4. Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways Archives of dermatological research · 2024
    5. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    6. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    7. Hair-Growth Promoting Effect and Anti-Inflammatory Mechanism of Ginkgo Biloba Polysaccharides Carbohydrate Polymers · 2021
    8. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    9. Morus Alba Root Extract Induces the Anagen Phase in Human Hair Follicle Dermal Papilla Cells Pharmaceutics · 2021
    10. Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021
    11. Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop Evidence-based Complementary and Alternative Medicine · 2021
    12. Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms Pharmaceutical Biology · 2020
    13. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    14. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    15. Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice Molecules · 2017
    16. Bioactives in Chinese Proprietary Medicine Modulate 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia Frontiers in Pharmacology · 2017
    17. A Hairy Fall: Syncope Resulting from Topical Application of Minoxidil Case Reports · 2015
    18. Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling Life Sciences · 2012
    19. Prevention and Treatment of Alopecia Areata with Quercetin in the C3H/HeJ Mouse Model Cell stress & chaperones · 2011
    20. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    21. Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata Archives of Dermatological Research · 1996

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