The Role of Moracin M in Promoting Hair Growth: Insights into Mechanisms of WNT/β-Catenin Pathway Activation and Angiogenesis Enhancement in Human Dermal Papilla Cells
November 2024
in “
Research Square (Research Square)
”
Moracin M Wnt/β-catenin signaling pathway angiogenesis human dermal papilla cells VEGF FGF2 KGF HGF MYC minoxidil cell proliferation MMP-2 MMP-9 Wnt signaling vascular endothelial growth factor fibroblast growth factor 2 keratinocyte growth factor hepatocyte growth factor c-Myc Rogaine matrix metalloproteinase-2 matrix metalloproteinase-9
Moracin M, a compound from the Moraceae family, has been shown to significantly enhance hair growth by promoting cell proliferation and angiogenesis in human dermal papilla cells (hDPCs). The study found that Moracin M activates the Wnt/β-catenin signaling pathway, leading to increased levels of growth factors such as VEGF, FGF2, KGF, HGF, and MYC, similar to the effects of minoxidil. It also enhances cell migration in human umbilical vein endothelial cells (HUVECs) without cytotoxicity at concentrations up to 50 µM. Additionally, Moracin M increases protein and mRNA levels of VEGF, FGF2, and KGF under inflammatory conditions and stimulates MMP-2 and MMP-9 expression, contributing to wound healing. These results suggest that Moracin M could be a promising alternative to current hair growth treatments.
