Prevention and Treatment of Alopecia Areata with Quercetin in the C3H/HeJ Mouse Model

March 2012 in “ Cell stress & chaperones ”

Tongyu C. Wikramanayake, Alexandra C. Villasante, Lucía Mercedes Mauro, Carmen Perez, Lawrence A. Schachner, Joaquín J. Jiménez

TLDR Quercetin effectively treated and prevented hair loss in mice.

The study demonstrated that quercetin, a plant flavonoid with anti-inflammatory properties, effectively treated and prevented alopecia areata (AA) in the C3H/HeJ mouse model. Subcutaneous quercetin injections led to hair regrowth in all treated mice with spontaneous AA, while none of the sham-treated mice showed improvement. Quercetin also prevented heat-induced AA, with no treated mice developing alopecia compared to 24% in the sham group, and reduced the onset of spontaneous AA to 4% in treated mice versus 18% in controls. The findings suggested quercetin's potential as a therapeutic agent for AA, likely due to its ability to reduce HSP70 expression and modulate immune responses, warranting further clinical studies.

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research Alopecia Areata Update

391 citations , February 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Complementary And Alternative Medicine In Alopecia Areata

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research Alopecia Areata Update

244 citations , February 2010 in “Journal of the American Academy of Dermatology”

The document says current treatments for alopecia areata do not cure or prevent it, and it's hard to judge their effectiveness due to spontaneous remission and lack of studies.

research 308-nm Excimer Laser for the Treatment of Alopecia Areata in Children

79 citations , September 2009 in “Pediatric dermatology”

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research An Update on Alopecia Areata

38 citations , August 2009 in “Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics”

Alopecia areata is a common autoimmune disease affecting hair follicles, with unclear causes and a need for better treatments.

research Alopecia Areata: Evidence-Based Treatments

71 citations , March 2009 in “Seminars in cutaneous medicine and surgery”

Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.

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Localized heat or specific injections can prevent chemotherapy-induced hair loss without affecting cancer treatment.

research Alopecia Areata: Overview and Treatment Options

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Alopecia areata causes hair loss, has no cure, and various treatments exist.

research Familial Aggregation of Alopecia Areata

295 citations , April 2006 in “Journal of the American Academy of Dermatology”

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research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle

185 citations , January 2006 in “Autoimmunity Reviews”

Alopecia areata is an autoimmune condition causing hair loss due to the immune system attacking hair follicles, often influenced by genetics and stress.

research The Pathogenesis of Alopecia Areata in Rodent Models

23 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.