Prevention and Treatment of Alopecia Areata with Quercetin in the C3H/HeJ Mouse Model

    November 2011 in “ Cell stress & chaperones ”
    Tongyu C. Wikramanayake, Alexandra C. Villasante, Lucía Mercedes Mauro, Carmen Perez, Lawrence A. Schachner, Joaquín J. Jiménez
    TLDR Quercetin effectively treated and prevented hair loss in mice.
    The study demonstrated that quercetin, a plant flavonoid with anti-inflammatory properties, effectively treated and prevented alopecia areata (AA) in the C3H/HeJ mouse model. Subcutaneous quercetin injections led to hair regrowth in all treated mice with spontaneous AA, while none of the sham-treated mice showed improvement. Quercetin also prevented heat-induced AA, with no treated mice developing alopecia compared to 24% in the sham group, and reduced the onset of spontaneous AA to 4% in treated mice versus 18% in controls. The findings suggested quercetin's potential as a therapeutic agent for AA, likely due to its ability to reduce HSP70 expression and modulate immune responses, warranting further clinical studies.
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