Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview

December 2023 in “ Biomolecules ”

Wuji Wang, Hong-Lan Wang, Yunluan Long, Zheng Li, Jingjie Li

apoptosis hair follicles hair loss hair follicle life cycle growth phase regression phase dormancy phase hair shedding hair growth hair regeneration programmed cell death hair cycle

TLDR Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

The review "Controlling Hair Loss by Regulating Apoptosis in Hair Follicles" explores the critical role of apoptosis in hair follicle cycles and its impact on hair loss, particularly during the catagen phase. It details both intrinsic and extrinsic apoptotic pathways, highlighting key proteins like caspase-3, Bcl-2, and Bax. The document discusses various natural and chemical agents, such as minoxidil, finasteride, and ginsenoside F2, that can modulate apoptosis to promote hair growth and prevent hair loss. The review emphasizes the need for further research to develop targeted therapies for different types of alopecia by understanding the mechanisms of apoptosis in hair follicles.

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