Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway

May 2022 in “ International journal of biological macromolecules ”

Bohao Zhao, Jiali Li, Xiyu Zhang, Yingying Dai, Neng Yang, Zhiyuan Bao, Yang Chen, Xinsheng Wu

exosomal miR-181a-5p dermal papilla cells hair follicle growth Wnt/β-catenin signaling pathway Wnt inhibitor WIF1 hair follicle stem cell proliferation hair follicle stem cell apoptosis miR-181a-5p DPC HF growth Wnt signaling WIF1 HFSC proliferation HFSC apoptosis

TLDR miR-181a-5p helps hair growth by activating a specific signaling pathway.

This study found that exosomal miR-181a-5p from dermal papilla cells (DPC) promotes hair follicle (HF) growth and development by activating the Wnt/β-catenin signaling pathway. The miR-181a-5p targets the Wnt inhibitor WIF1, leading to increased HF stem cell (HFSC) proliferation and reduced HFSC apoptosis. The findings suggest that miR-181a-5p could serve as a novel biomarker and therapeutic target for hair-related diseases and wool production in mammals. The study involved in vitro culture of HF organs and demonstrated the positive role of miR-181a-5p in hair growth.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

13 / 13 results

research Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration

19 citations , June 2021 in “Tissue Engineering and Regenerative Medicine”

Fat stem cell particles help regrow hair.

research Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion

9 citations , June 2021 in “Nutrients”

Fisetin in fruits and vegetables helps hair growth in mice.

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , July 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

38 citations , June 2019 in “International Journal of Molecular Sciences”

Tiny particles called extracellular vesicles could help with skin healing and hair growth, but more research is needed.

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

Non-coding RNAs play key roles in the hair growth cycle of Angora rabbits.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research TGFβ Family Mimetic Peptide Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice

9 citations , September 2018 in “Biomedical dermatology”

A peptide called DPS-1 helps human scalp cells grow and stimulates hair growth in mice.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , June 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Hair Follicle Stem Cells

142 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.

2 / 2 results

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Trans‐species hair growth induction by human hair follicle dermal papillae

66 citations , August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.