Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway

March 2022 in “ International journal of biological macromolecules ”

Bohao Zhao, Jiali Li, Xiyu Zhang, Yingying Dai, Neng Yang, Zhiyuan Bao, Yang Chen, Xinsheng Wu

exosomal miR-181a-5p dermal papilla cells hair follicle growth Wnt/β-catenin signaling pathway Wnt inhibitor WIF1 hair follicle stem cell proliferation hair follicle stem cell apoptosis miR-181a-5p DPC HF growth Wnt signaling WIF1 HFSC proliferation HFSC apoptosis

TLDR miR-181a-5p helps hair growth by activating a specific signaling pathway.

This study found that exosomal miR-181a-5p from dermal papilla cells (DPC) promotes hair follicle (HF) growth and development by activating the Wnt/β-catenin signaling pathway. The miR-181a-5p targets the Wnt inhibitor WIF1, leading to increased HF stem cell (HFSC) proliferation and reduced HFSC apoptosis. The findings suggest that miR-181a-5p could serve as a novel biomarker and therapeutic target for hair-related diseases and wool production in mammals. The study involved in vitro culture of HF organs and demonstrated the positive role of miR-181a-5p in hair growth.

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