Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

May 2019 in “ Frontiers in genetics ”

Bohao Zhao, Yang Chen, Shuaishuai Hu, Neng Yang, Manman Wang, Ming Liu, Jiali Li, Yeyi Xiao, Xinsheng Wu

Studysummary This study reported that specific non-coding RNAs may regulate the hair follicle cycle in Angora rabbits by acting as competitive endogenous RNAs, enhancing understanding of ncRNA roles in hair growth. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the role of non-coding RNAs (ncRNAs) in the hair follicle (HF) cycle of Angora rabbits using RNA sequencing. Researchers identified 111 long non-coding RNAs (lncRNAs), 247 circular RNAs (circRNAs), 97 microRNAs (miRNAs), and 1,168 mRNAs that were differentially expressed during the HF growth stages. Validation was done using quantitative real-time PCR, and analyses such as Gene Ontology (GO) and KEGG pathway provided insights into the roles of these ncRNAs and mRNAs. The study also constructed ceRNA networks, identifying LNC_002919 and novel_circ_0026326 as key regulators acting as miR-320-3p sponges. This research highlighted the potential regulatory roles of ncRNAs in hair growth and provided a foundation for further studies on HF cycle regulation.

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