Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep

    August 2024 in “ Current Issues in Molecular Biology ”
    Jiaqi Fu, Xinyu Zhang, Dan Wang, Wenqing Liu, Caihong Zhang, Wei Wang, Wei Fan, Lichun Zhang, Fuliang Sun
    Image of study
    TLDR Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.
    This study analyzed the expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the skin tissue of Super Merino (SM) and Small-Tailed Han (STH) sheep, identifying 20,888 lncRNAs and 31,579 mRNAs, with 56 lncRNAs and 616 mRNAs being differentially expressed. Key genes involved in hair follicle growth, such as RAC2, WNT11, and FZD2, were confirmed through immunohistochemistry. Specific lncRNAs like MSTRG.9225.1, MSTRG.98769.1, and MSTRG.84658.1 were found to potentially regulate hair follicle growth by targeting genes such as LOC114113396, FGF1, IGF1, and RAC2. These findings provide a foundation for future sheep breeding improvements and further studies on hair follicle development.
    Discuss this study in the Community →

    Research cited in this study

    20 / 20 results

    Related Community Posts Join

    6 / 1000+ results

      community My Current Hairloss Stack (No Finasteride)

      in Update  11 upvotes 1 year ago
      Hair loss treatments, specifically Minoxidil, Fluridil & Alfatradiol, Nizoral, Saw Palmetto, Hairmetto and Microneedling. The user mentioned they have seen a decrease in shedding and improvement in the quality/density of their hair since using this stack, but opted out of trying Finasteride due to potential side effects.

      community What ever happened to pyrilutamide?

      in Technology  49 upvotes 1 year ago
      Pyrilutamide, a potentially effective hair loss treatment; other topical treatments like RU58841 and CB-03-01 that may have fewer side effects than Pyrilutamide; and the Phase 3 clinical trials of Pyrilutamide, which is likely to be approved by the FDA soon.

      community A year of fin+min(23yo), got my life back

      in Progress Pictures  2187 upvotes 1 year ago
      A 23 year old user who has had success with finasteride and minoxidil, regaining their hair after losing it due to male pattern baldness. They also attribute part of the success to lifestyle changes such as eating better, exercising, sleeping well, and reducing smoking.

      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community So we’re just ok with taking a research chemical now?

      in Treatment  181 upvotes 3 years ago
      The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.

    Similar Research

    5 / 1000+ results