Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep

    August 2024 in “ Current Issues in Molecular Biology ”
    Jiaqi Fu, Xinyu Zhang, Dan Wang, Wenqing Liu, Caihong Zhang, Wei Wang, Wei Fan, Lichun Zhang, Fuliang Sun
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    TLDR Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.
    This study analyzed the expression profiles of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the skin tissue of Super Merino (SM) and Small-Tailed Han (STH) sheep, identifying 20,888 lncRNAs and 31,579 mRNAs, with 56 lncRNAs and 616 mRNAs being differentially expressed. Key genes involved in hair follicle growth, such as RAC2, WNT11, and FZD2, were confirmed through immunohistochemistry. Specific lncRNAs like MSTRG.9225.1, MSTRG.98769.1, and MSTRG.84658.1 were found to potentially regulate hair follicle growth by targeting genes such as LOC114113396, FGF1, IGF1, and RAC2. These findings provide a foundation for future sheep breeding improvements and further studies on hair follicle development.
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