Association Between Mesenchymal Stem Cells and COVID-19 Therapy: Systematic Review and Current Trends

January 2022 in “ BioMed Research International ”

Amaan Javed, Saurab Karki, Zeba Sami, Zuha Khan, Anagha Shree, Biki Kumar Sah, Shankhaneel Ghosh, Sara Saxena

mesenchymal stem cells MSC MSC exosomes hair follicle mesenchymal stem cells HF-MSCs

Studysummary This review found that mesenchymal stem cells and their derived exosomes are a potentially safe and well-tolerated treatment for lung healing in patients with COVID-19.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The systematic review analyzed 22 studies on the use of mesenchymal stem cells (MSC) from health cord tissues in treating COVID-19 patients. The studies found that MSC exosomes are safer than MSC alone due to their smaller size and lesser immunological response. They also found that the lungs healed with the use of exosomes. MSCs were found to increase the angiogenesis process and alveolar reepithelization, reducing markers like TNF alpha, TGF beta, and COL I and III, reducing the growth of myofibroblasts and increasing survivability of endothelium leading to attenuated pulmonary fibrosis and even reversing them. The review concluded that the use of MSCs or their derived exosomes is safe and well-tolerated in COVID-19 patients, improving oxygenation parameters and aiding in lung healing. In the context of hair regrowth, hair follicle mesenchymal stem cells (HF-MSCs) have shown potential in advancing hair growth.

View this study on downloads.hindawi.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations , January 2020 in “Skin Pharmacology and Physiology”

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.

research Conventional and Novel Stem Cell-Based Therapies for Androgenic Alopecia

22 citations , August 2017 in “Stem cells and cloning”

This review analyzes therapies used for androgenic alopecia, highlighting potential advances from stem cell technologies and regenerative medicine, and reports no new clinical results.

research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells

22 citations , April 2006 in “Journal of Dermatological Science”

This study reports that versican expression plays a crucial role in maintaining the anagen phase and hair inductive properties, as shown in a transgenic mouse model and hair growth assays.