Exosomes And Hair Regeneration: A Systematic Review Of Clinical Evidence Across Alopecia Types And Exosome Sources

    September 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Mohammed Al Ameer, Abdulaziz Alnajim, Ali Al Ameer, Zainab A. Alsalman, Ghadeer Al Ameer, Sarah Alnajim, Anwar A. Alghamdi, Raniya Moideen, Enas Al Hadi
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    TLDR Exosome therapy shows promise for hair growth with minimal side effects, but more research is needed.
    This systematic review assesses the safety and effectiveness of mesenchymal stem cell (MSC)-derived exosome therapy for hair growth, focusing on androgenetic alopecia (AGA) and other hair loss types. It includes 11 studies with 298 patients, featuring various study designs. Exosomes from sources like adipose tissue, placenta, and foreskin showed improvements in hair density and thickness, with high patient satisfaction and minimal adverse effects. Notably, adipose-derived exosomes, especially when combined with microneedling, demonstrated significant efficacy. Despite promising results, the evidence is limited by study heterogeneity and small sample sizes, indicating a need for more standardized, high-quality randomized controlled trials to confirm these findings and establish treatment protocols.
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      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 3 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 1 year ago
      A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

      community Anyone got any regrowth with exosomes?

      in Treatment  2 upvotes 3 months ago
      Exosomes are being considered for hair regrowth after using finasteride and minoxidil, with skepticism about their effectiveness and high cost. Users discuss administration methods like injections and microneedling, but concerns about pricing and potential scams are prevalent.

      community Has anyone tried Exosomes from Musely or somewhere else?

      in Hair Systems  11 upvotes 7 months ago
      Exosomes from Musely are being discussed as a topical hair loss treatment containing ingredients like latanoprost, caffeine, cetirizine, melatonin, vitamin D3, vitamin E, and biotin. Users are curious about its effectiveness and potential side effects, noting it may take 4-6 months to see results.

      community Exosomes therapy -- any personal experience?

      in Treatment  3 upvotes 9 months ago
      Exosome therapy for hair loss is being discussed, with mixed personal experiences and no significant results reported by some users. The treatment is expensive, and users are skeptical about its effectiveness.

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