Use of Exosomes in Hair Therapy: A Systematic Review

This systematic review evaluates the potential of exosomes in hair therapy, particularly for androgenetic alopecia. Exosomes, derived from mesenchymal stem cells, show promise in increasing hair density, extending the anagen phase, and reducing follicular miniaturization. They act by modulating the follicular microenvironment, promoting angiogenesis, and activating key signaling pathways like Wnt/ẞ-catenin. While animal and limited human studies indicate significant improvements in hair quality, the lack of standardized protocols and limited randomized clinical trials are major limitations. No serious adverse effects have been reported, but further long-term studies are needed to assess safety and efficacy. Regulatory approval remains a challenge, and more robust clinical trials are necessary to facilitate the clinical adoption of exosome-based therapies for hair loss.