Topical Application of Bio-Pulsed Avian MSC-Derived Extracellular Vesicles Enhances Hair Regrowth and Skin Rejuvenation: Evidence from Clinical Evaluation and miRNA Profiling

    July 2025 in “ Current Issues in Molecular Biology ”
    Ju-Sheng Shieh, Yu‐Tang Chin, Tsu‐Te Yeh … Shih-Ching Wang
    Studysummary This study evaluated the safety and efficacy of Bio-Pulsed avian mesenchymal stem cell-derived small extracellular vesicles when applied topically, finding significant improvements in hair growth, skin rejuvenation, and regenerative microRNA presence among 60 human participants without adverse events.
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    Research cited in this study 8

    1. Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia Journal of Controlled Release · 2025
    2. Efficacy, Safety, and Tolerability of Drugs for Alopecia: A Comprehensive Review Expert Opinion on Drug Metabolism & Toxicology · 2025
    3. Exosomes: Historical Evolution and Emerging Roles in Dermatology Journal of Cosmetic Dermatology · 2025
    4. Exosomes in Cosmetic Dermatology: A Review of Benefits and Challenges Journal of Drugs in Dermatology · 2024
    5. Cell Therapy for Androgenetic Alopecia: Elixir or Trick? Stem cell reviews and reports · 2023
    6. Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells International journal of molecular sciences · 2022
    7. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    8. Standardizing the 60-Second Hair Count Archives of Dermatology · 2008