Efficacy, Safety, and Tolerability of Drugs for Alopecia: A Comprehensive Review

    Jair Alejandro Valdez-Zertuche, Hassiel Aurelio Ramírez-Marín, Antonellá Tosti
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    This comprehensive review examines the efficacy, safety, and tolerability of pharmacological treatments for different types of alopecia, including androgenetic alopecia (AGA), alopecia areata (AA), and scarring alopecias. For non-scarring alopecia, treatments like finasteride, minoxidil, JAK inhibitors, and antiandrogens such as spironolactone are highlighted. JAK inhibitors, particularly baricitinib, show potential for AA but require careful monitoring due to immune suppression risks. Scarring alopecias are managed with systemic agents like hydroxychloroquine and corticosteroids, supplemented by topical and laser therapies. The review suggests that the future of alopecia treatment will be transformed by emerging targeted therapies, regenerative medicine, and advanced delivery systems, promising improved outcomes through personalized and mechanism-targeted approaches.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  814 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community Should I get transplant #4 or just shave my head?

      in Transplants  175 upvotes 6 months ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.
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      community What else is good. Besides the big 3.

      in Chat  34 upvotes 4 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community M24 Finasteride (4M) minoxidil (2Y)

      in Progress Pictures  57 upvotes 1 year ago
      FalseHour6541's two-year experience with Minoxidil and Finasteride, resulting in good density on their crown; other users suggested a hair transplant to help reduce the receding hairline.

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