Minoxidil Dose Response Study in Female Pattern Hair Loss Patients Determined to Be Non-Responders to 5% Topical Minoxidil

A study was conducted to determine if increasing the dosage of topical minoxidil would increase the number of responders without increasing adverse events in female pattern hair loss (FPHL) patients who were non-responders to 5% topical minoxidil. The study recruited FPHL subjects who were identified as non-responders to 5% topical minoxidil and treated them for 12 weeks with a novel 15% topical minoxidil solution. At 12 weeks, 60% of subjects achieved a clinically significant response based on target area hair counts and significant improvement in global photographic assessment. None of the subjects experienced significant hemodynamics changes or any other adverse events. This study demonstrates the potentially beneficial effect of a higher dosage of minoxidil in FPHL subjects that fail to respond to 5% minoxidil.