Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions

November 2023 in “ Frontiers in immunology ”

Thierry Passeron, Brett King, Julien Sénéschal, Martin Steinhoff, Ali Jabbari, Manabu Ohyama, Desmond J. Tobin, Simran Randhawa, Aaron Winkler, Jean‐Baptiste Telliez, David Martin, Alexandre Lejeune

alopecia areata immune privilege hair follicles CD8+ T cells JAK1/2 inhibitor baricitinib JAK3/TEC inhibitor ritlecitinib T-cell signaling pathways AA JAK inhibitors

TLDR New treatments targeting T-cell pathways are needed for better alopecia areata management.

Alopecia areata (AA) is an autoimmune condition causing hair loss due to the collapse of immune privilege at hair follicles and subsequent attack by autoreactive CD8+ T cells. Current FDA-approved treatments for severe AA include the JAK1/2 inhibitor baricitinib and the JAK3/TEC inhibitor ritlecitinib. However, these options are limited, and other off-label treatments have issues with efficacy and safety. This review highlights the central role of T cells in AA and discusses drugs in development that target T-cell signaling pathways. It emphasizes the need for therapies that address multiple T-cell pathways and provides expert insights into future directions for AA treatment development.

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4 / 4 results

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