Resident Memory T Cells in Autoimmune Skin Diseases

Three years ago, the document "Resident Memory T Cells in Autoimmune Skin Diseases" explored the role of resident memory T cells in autoimmune skin diseases like alopecia areata, lupus erythematosus, and psoriasis. The study identified the collapse of immune privilege in the hair follicle's epithelial stem cell niche as a feature of alopecia areata, implicating both innate and adaptive immunity in the disease's development. The paper also discussed the use of JAK inhibitors, such as tofacitinib and ruxolitinib, in reversing alopecia areata by targeting cytotoxic T lymphocytes. The effectiveness of these treatments was backed by several studies, including one where oral ruxolitinib induced hair regrowth in patients with moderate-to-severe alopecia areata.