Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

    September 2018 in “ Dermatologic therapy ”
    Christine C. Yang, Trisha Khanna, B. Sallee, Angela M. Christiano, Lindsey Bordone
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    TLDR Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.
    In this case series, 10 patients with recalcitrant lichen planopilaris (LPP) were treated with oral tofacitinib, a Janus kinase (JAK) inhibitor, at doses of 5 mg twice or three times daily for 2–19 months. The treatment was administered either as monotherapy or in combination with other therapies. Eight patients showed clinical improvement, with significant reductions in the LPP Activity Index (LPPAI) from an average of 6.22 before treatment to 3.08 after treatment (p = .0014), indicating a reduction in LPPAI ranging from 30 to 94%. One patient experienced a 10-pound weight gain, but no other adverse effects were reported. The study concluded that oral tofacitinib could lead to measurable improvement in recalcitrant LPP.
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      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 4 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 2 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 2 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

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