301 citations
,
February 2019 in “Nature Communications” In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
79 citations
,
January 2019 in “International Journal of Molecular Sciences” This study characterized the inflammatory response in a murine burn model, revealing similarities to human burns and supporting the model's use in testing therapies for burn complications.
1160 citations
,
November 2018 in “Physiological Reviews” This review discusses the potential of single cell technologies to improve understanding and treatment of impaired wound healing and reports no new clinical results.
130 citations
,
September 2018 in “Cell Reports” This study found that macrophages play a crucial role in nerve regeneration by regulating Schwann cell dynamics and remyelination, with Gas6 identified as a key factor in this process.
83 citations
,
June 2018 in “Frontiers in immunology” This review discusses the roles of αβ and γδ T cells in skin health and disease and reports no new clinical results; the authors highlight potential therapeutic developments.
24 citations
,
March 2018 in “Experimental Dermatology” This review explores the role of regulatory T cells in autoimmune skin disorders like alopecia areata and vitiligo, emphasizing unanswered questions and reporting no new experimental results.
29 citations
,
February 2018 in “European Journal of Immunology” In this study, Treg depletion impaired skin wound healing in mice, potentially by altering the cytokine environment and expanding certain T-cell populations, disrupting the normal healing process.
79 citations
,
January 2018 in “Wiley Interdisciplinary Reviews-Developmental Biology” This review discusses the experimental targets of fetal wound healing and evaluates existing therapies for scarless healing in adult skin, but reports no new research findings.
110 citations
,
July 2017 in “Immunology” This review discusses the role of regulatory T cells in skin, including their impact on hair follicle regeneration, wound healing, and immune tolerance, without presenting new clinical findings.
65 citations
,
May 2017 in “Advances in wound care” This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.
65 citations
,
February 2017 in “Pflügers Archiv - European Journal of Physiology” This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.
178 citations
,
August 2016 in “Advances in wound care” This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.
155 citations
,
May 2016 in “Nature communications” This study found that mouse skin CD4(+) memory T cells are in equilibrium with the circulation under steady state but increase in specific clusters in response to infection or inflammation.
25 citations
,
November 2015 in “Journal of Dermatological Science” In this study, researchers identified the antimicrobial peptide dermcidin in sebocyte lipid droplets, challenging the previous understanding of dermcidin as exclusively sweat-specific.
245 citations
,
October 2015 in “Nature medicine” The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.
701 citations
,
August 2014 in “Nature medicine” This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.
426 citations
,
August 2014 in “Nature Medicine” This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.
218 citations
,
May 2014 in “Experimental Dermatology” This review explores the evolution and development of skin-associated adipose tissue and proposes new nomenclature for the cells and adipose tissue underlying the reticular dermis, without reporting clinical results.
610 citations
,
April 2014 in “Nature Reviews Immunology” This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.
64 citations
,
August 2013 in “Mayo Clinic Proceedings” This review discusses current concepts in wound repair and suggests that these evolving paradigms might also explain regenerative processes in various organ systems, but it reports no new research findings.
286 citations
,
June 2012 in “Nature Immunology” In this study, researchers found that mouse hair follicles recruit Langerhans cells by secreting chemokines, acting as key portals for these cells in both mice and humans.
195 citations
,
December 2009 in “Journal of Investigative Dermatology” This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.
