Toll-Like Receptor Function in Acute Wounds

    May 2017 in “ Advances in wound care ”
    Lin Chen, Luisa A. DiPietro
    Image of study
    TLDR Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.
    The document from 2017 reviews the role of Toll-like receptors (TLRs) in acute and diabetic wound healing, highlighting their presence in various cell types involved in the healing process. TLRs are crucial for recognizing pathogens and damaged cells, and their signaling pathways are important in regulating inflammation, cytokine expression, reepithelialization, granulation, and angiogenesis during wound repair. The review notes that TLRs are significantly elevated in mouse skin wounds and that deficiencies in TLR2, 3, 4, or 9 result in delayed wound healing in mice. In diabetic mice, TLR2 and TLR4 signaling pathways are associated with slower wound closure, suggesting that TLR-mediated inflammation may impede healing. Additionally, microRNAs are mentioned as regulators of gene expression, including TLR signaling, and their negative regulation is important for wound healing. The authors call for more research to fully understand the specific roles of TLRs and their ligands in wound healing, as well as the implications for human skin wounds and chronic wounds. The research was supported by NIH grants.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 62 results

      community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

       136 upvotes 6 years ago
      Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.
      [object Object]

      community Why does MPB only affect the scalp

      in Research/Science  14 upvotes 1 month ago
      Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

      community Hairloss is mentally exhausting

      in Chat  25 upvotes 4 years ago
      The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

      community Why only the top of the head?!

      in Chat 2 years ago
      Why the top of the head is affected by hair loss more than other areas, and treatments such as surgery, medications like minoxidil, finasteride, and RU58841 to treat it.

      community I think we all hop on estrogen. It's the only angle

      in Satire  83 upvotes 5 months ago
      The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

    Similar Research

    5 / 836 results