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GlossaryToll-like receptors

proteins on immune cells that detect pathogens and trigger responses

Toll-like receptors (TLRs) are proteins found on the surface of certain cells that play a crucial role in the immune system by recognizing and responding to pathogens like bacteria and viruses. They act as sentinels, detecting foreign molecules and triggering an immune response to help protect the body from infections.

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research Altered Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

12 citations, March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

research To Identify the Expression of Intracellular Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Alopecia Areata

November 2023

Alopecia areata patients have higher levels of certain immune receptors, suggesting new treatment possibilities.

research Toll-Like Receptor Function in Acute Wounds

65 citations, May 2017 in “Advances in wound care”

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Deregulation of Toll Like Receptor Signaling and Association With Caveolin-1 in Lichen Planopilaris Reveals a Novel Mechanism in Pathogenesis of Scarring Alopecia

research Deregulation of Toll Like Receptor Signaling and Association With Caveolin-1 in Lichen Planopilaris Reveals a Novel Mechanism in Pathogenesis of Scarring Alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The study suggests that changes in immune system receptors and their interaction with a cell component may be important in the development of a type of hair loss condition.

research Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

6 citations, November 2021 in “Frontiers in immunology”

STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

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community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

136 upvotes 6 years ago

Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

community Why does MPB only affect the scalp

in Research/Science 14 upvotes 3 days ago

Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

community Hairloss is mentally exhausting

in Chat 25 upvotes 4 years ago

The conversation is about the mental toll of hair loss and seeking alternatives to finasteride. Suggestions include using minoxidil, considering pumpkin seed oil, and possibly seeking counseling for body dysmorphic disorder.

community Why only the top of the head?!

in Chat 2 years ago

Why the top of the head is affected by hair loss more than other areas, and treatments such as surgery, medications like minoxidil, finasteride, and RU58841 to treat it.

community I think we all hop on estrogen. It's the only angle

in Satire 83 upvotes 4 months ago

The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

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