Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

November 2021 in “ Frontiers in immunology ”

Katsumi Miyauchi, Sewon Ki, Masao Ukai, Yasufumi Suzuki, Kentaro Inoue, Wataru Suda, Toshinori Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko Tanaka, Mariko Okada‐Hatakeyama, Masato Kubo

STAT3 signaling keratinocytes hair follicle-specific keratin genes atopic dermatitis hyper IgE syndrome type 17 helper T cell Toll-like receptors inflammatory responses skin homeostasis STAT3 skin cells hair keratin genes eczema high IgE syndrome Th17 cells TLRs inflammation skin health

TLDR STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

STAT3 signaling in keratinocytes is crucial for maintaining skin homeostasis, as it negatively regulates the expression of hair follicle-specific keratin genes. Disruptions in STAT3 signaling are linked to atopic dermatitis in hyper IgE syndrome, which is thought to be due to defects in type 17 helper T cell specification. The study also found that the onset of dermatitis correlated with these gene expression patterns and occurred under specific pathogen-free conditions, but not in germ-free conditions, indicating that inflammatory responses triggered by Toll-like receptors due to microorganisms are involved. This highlights the importance of STAT3-dependent gene expression in keratinocytes for skin health.

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Research cited in this study

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research The Role of the Microbiome in Scalp Hair Follicle Biology and Disease

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research Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

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Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

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research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

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research Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation

49 citations, October 2009 in “Cancer research”

Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.

research Hair Follicle-Specific Keratins And Their Diseases

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research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice

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research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations, November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

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