Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

November 2021 in “ Frontiers in immunology ”

Katsumi Miyauchi, Sewon Ki, Masao Ukai, Yasufumi Suzuki, Kentaro Inoue, Wataru Suda, Toshinori Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko Tanaka, Mariko Okada‐Hatakeyama, Masato Kubo

STAT3 signaling keratinocytes hair follicle-specific keratin genes atopic dermatitis hyper IgE syndrome type 17 helper T cell Toll-like receptors inflammatory responses skin homeostasis STAT3 skin cells hair keratin genes eczema high IgE syndrome Th17 cells TLRs inflammation skin health

TLDR STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

STAT3 signaling in keratinocytes is crucial for maintaining skin homeostasis, as it negatively regulates the expression of hair follicle-specific keratin genes. Disruptions in STAT3 signaling are linked to atopic dermatitis in hyper IgE syndrome, which is thought to be due to defects in type 17 helper T cell specification. The study also found that the onset of dermatitis correlated with these gene expression patterns and occurred under specific pathogen-free conditions, but not in germ-free conditions, indicating that inflammatory responses triggered by Toll-like receptors due to microorganisms are involved. This highlights the importance of STAT3-dependent gene expression in keratinocytes for skin health.

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Research cited in this study

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