TLDR STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.
STAT3 signaling in keratinocytes is crucial for maintaining skin homeostasis, as it negatively regulates the expression of hair follicle-specific keratin genes. Disruptions in STAT3 signaling are linked to atopic dermatitis in hyper IgE syndrome, which is thought to be due to defects in type 17 helper T cell specification. The study also found that the onset of dermatitis correlated with these gene expression patterns and occurred under specific pathogen-free conditions, but not in germ-free conditions, indicating that inflammatory responses triggered by Toll-like receptors due to microorganisms are involved. This highlights the importance of STAT3-dependent gene expression in keratinocytes for skin health.
73 citations,
April 2019 in “Experimental Dermatology” The scalp's microorganisms significantly affect hair health and disease.
245 citations,
October 2015 in “Nature medicine” Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.
220 citations,
June 2013 in “The Journal of Pathology” 286 citations,
June 2012 in “Nature Immunology” Hair follicles help attract immune cells to the skin during stress.
49 citations,
October 2009 in “Cancer research” Disrupting Stat3 in hair follicle stem cells greatly reduces skin tumor formation.
138 citations,
March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
49 citations,
August 2004 in “The FASEB Journal” Mice with human skin protein K8 had more skin problems and cancer.
73 citations,
November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
3 citations,
March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
26 citations,
May 2014 in “BioEssays” Using neurohormones to control keratin can lead to new skin disease treatments.
19 citations,
September 2019 in “EMBO molecular medicine” Blocking TSLP reduces skin inflammation and cell overgrowth in psoriasis.
52 citations,
October 2012 in “Journal of Dermatological Science” The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” AP-2α and AP-2β proteins are essential for healthy adult skin and hair.
