Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

    November 2021 in “ Frontiers in immunology ”
    Katsumi Miyauchi, Sewon Ki, Masao Ukai … Masato Kubo
    Studysummary This study suggests that STAT3 signaling in keratinocytes is crucial for maintaining skin homeostasis by regulating hair follicle-specific keratin genes, potentially impacting dermatitis development through microbe-triggered inflammatory responses.
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    Research cited in this study 14

    1. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    2. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018
    3. Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma Nature medicine · 2015
    4. Constitutive Stat3 Activation Alters Behavior of Hair Follicle Stem and Progenitor Cell Populations Molecular Carcinogenesis · 2013
    5. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    6. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    7. Keratin Gene Mutations in Disorders of Human Skin and Its Appendages Archives of Biochemistry and Biophysics · 2010
    8. Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation Cancer research · 2009
    9. Impact of Stat3 Activation Upon Skin Biology: A Dichotomy of Its Role Between Homeostasis and Diseases Journal of Dermatological Science · 2007
    10. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    11. Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice The FASEB Journal · 2004
    12. Tissue Regeneration: Hair Follicle as a Model Journal of Investigative Dermatology Symposium Proceedings · 2001
    13. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    14. Directed Expression of Keratin 16 to the Progenitor Basal Cells of Transgenic Mouse Skin Delays Skin Maturation The Journal of Cell Biology · 1998