A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

March 2023 in “ International journal of molecular sciences ”

Ekaterina P. Kalabusheva, Anastasia S. Shtompel, A. Rippa, Sergey V. Ulianov, Sergey V. Razin, E. A. Vorotelyak

keratin genes epithelial cells chromatin compartmentalization topologically associated domains TADs transcription factors KLF4 CTCF enhancers promoters keratinocyte differentiation keratin gene misregulation hereditary disorders

TLDR Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

The document "A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms" explores the complex regulation and expression of keratin genes, which are essential for the structural integrity and function of epithelial cells. It highlights the roles of chromatin compartmentalization, topologically associated domains (TADs), and transcription factors like KLF4 and CTCF in regulating keratin genes. The study discusses the dynamic interactions between enhancers and promoters during keratinocyte differentiation and the implications of keratin gene misregulation in diseases such as cancer and hereditary disorders. The research underscores the importance of understanding these regulatory mechanisms for potential therapeutic interventions.

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