DNA Dioxygenases Tet2/3 Regulate Gene Promoter Accessibility and Chromatin Topology in Lineage-Specific Loci to Control Epithelial Differentiation

    January 2023 in “ Science advances ”
    Guodong Chen, Iqra Fatima, Qin Xu … Vladimir A. Botchkarev
    Studysummary This study found that ablation of Tet2/Tet3 genes in skin epithelial cells altered hair shape and length, leading to hair loss, by affecting chromatin accessibility and gene expression related to hair follicle regulation.
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    Research cited in this study 14

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