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    Glossary Dlx3

    gene crucial for hair follicle and skin development

    Dlx3 is a gene that plays a crucial role in the development and differentiation of hair follicles, skin, and teeth. It is part of the Distal-less homeobox (Dlx) family of transcription factors, which are essential for regulating the expression of other genes during embryonic development. Mutations in Dlx3 have been linked to conditions such as Tricho-Dento-Osseous (TDO) syndrome, which affects hair, teeth, and bone development.

    Research 10 of 135

    1. Dlx3 is a crucial regulator of hair follicle differentiation and cycling Development · 2008 · 132 citations
    2. Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes Nucleic Acids Research · 2002 · 79 citations
    3. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene 2012 · 17 citations
    4. Roles for Msx and Dlx homeoproteins in vertebrate development Gene · 2000 · 234 citations
    5. Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle ˜The œFASEB journal · 2010 · 149 citations
    6. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    7. CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis Journal of Investigative Dermatology · 2013 · 9 citations
    8. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation Science advances · 2023 · 3 citations
    9. Human basal cell carcinoma: the induction of anagen hair follicle differentiation Clinical and experimental dermatology · 2019 · 3 citations
    10. Integrated transcriptomic and proteomic analysis reveals molecular mechanisms of melatonin-regulated hair follicle growth in cashmere goats and comparative insights across goat breeds BMC Genomics · 2025
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