Murine Sebaceous Gland Homeostasis Requires Intact Cutaneous Innervation in a Hair Cycle-Dependent Context

    September 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    R. Clayton, Eleanor Hinde, Xinhong Lim, Ralf Paus, M.A.M. van Steensel
    Image of study
    TLDR Mouse skin glands need healthy nerves to grow properly during hair growth phases.
    The study investigated the relationship between cutaneous nerves and sebaceous gland (SG) function in mice. It was found that while cutaneous nerves are not essential for the basic maintenance of SGs during the resting phase of the hair cycle (telogen), they are necessary for the upregulation of SG size during the active growth phase (anagen) and when hair growth is stimulated by waxing depilation. The research revealed that SGs undergo changes in size, sebocyte area, and sebocyte number in coordination with the hair cycle, and that these changes are nerve-dependent. Additionally, the study showed that the recruitment of Lrig1+ stem cells to the SG during hair growth is reduced in the absence of intact innervation. These findings suggest a functional link between SGs and hair follicles, and imply that neuromodulators might be used to treat SG-related skin conditions by altering sebum production.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 100 results

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community For those who switched from finasteride to Dutasteride !

      in Chat  43 upvotes 2 years ago
      People discussed switching from finasteride to dutasteride for hair loss treatment. They reported satisfaction with dutasteride, noting it was more effective than finasteride, particularly after finasteride's effects diminished, and some experienced additional benefits like cost savings and stabilized hair loss, rating dutasteride highly as a treatment.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  132 upvotes 1 year ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

      community Is GT20029 supposed to regrow hair as well?

      in Treatment  10 upvotes 2 years ago
      The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

    Related Research

    6 / 6 results