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research Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin

115 citations , November 2004 in “Brain Behavior and Immunity”

This study found that stress increases the number of peptidergic nerve fibers and mast cell activity in mouse skin, suggesting a significant neuro-immune interaction under stress.

research Neurotrophin-4 modulates the mechanotransducer Cav3.2 T-type calcium current in mice down-hair neurons

11 citations , September 2011 in “Biochemical journal”

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

research 574 Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycle-dependent context

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, mouse sebaceous glands were found to require nerves for growth during active hair cycles, suggesting a nerve-dependent sebaceous gland cycle coordinated with hair growth.

research 51012 Clinical and pathophysiological study of seborrheic capitis: focus on brain-skin connection

September 2024 in “Journal of the American Academy of Dermatology”

Seborrheic dermatitis affects quality of life and sleep, linked to stress and nervous system changes.

research Cutaneous Manifestations of Chronic Kidney Disease: A Narrative Review

January 2026 in “Journal of Biosciences and Medicines”

This research highlights the common and varied skin-related symptoms associated with chronic kidney disease, emphasizing that early recognition and multi-pronged management involving nephrology and dermatology can improve patient outcomes.

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community Treatment of Finasteride Induced Gynecomastia (Male breast tissue growth)

16 upvotes 5 years ago

Finasteride can cause gynecomastia, which may be reversible by stopping the drug and using selective estrogen receptor modulators (SERMs) like tamoxifen. Lifestyle changes such as weight loss and avoiding alcohol can also help, but surgery may be needed if the condition persists.

community BPC-157 and Angiogenesis. Bro-Science-Execution-Plan

in Research/Science 13 upvotes 1 year ago

BPC-157 may promote hair growth by increasing angiogenesis, similar to how Minoxidil works, though no direct research confirms this yet. Users report combining BPC-157 with Minoxidil and finasteride for better results, but concerns about long-term safety exist.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 2 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Finasteride and shooting nerve pain

1 upvotes 5 days ago

A user experienced shooting nerve pain in the groin area after starting finasteride and plans to retry the medication after a break to see if symptoms recur. Another user suggests the pain is more likely due to physical activity, not the medication.

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