Success and Controversy of Natural Products as Therapeutic Modulators of Wnt Signaling and Its Interplay with Oxidative Stress: Comprehensive Review Across Compound Classes and Experimental Systems

    May 2025 in “ Antioxidants ”
    Alexey Koval, Nilufar Z. Mamadalieva, Rano Mamadalieva, Fazliddin Sodiqovich Jalilov, Vladimir L. Katanaev
    TLDR Natural products show promise for treating diseases but need more research to understand and use them effectively.
    The review examines the role of natural products in modulating the Wnt signaling pathway and their interaction with oxidative stress, highlighting their potential therapeutic applications in diseases such as cancer, fibrosis, and neurodegenerative disorders. It discusses various natural compounds, including cardiac glycosides, steroid saponins, ecdysteroids, withanolides, cucurbitacins, triterpenes, iridoids, terpenoids, coumarins, flavonoids, phenolics, and N-containing compounds, which have shown both inhibitory and activating effects on Wnt signaling across different experimental systems. The review emphasizes the complexity and context-dependent nature of these compounds' effects, underscoring the need for further research to fully understand their mechanisms and optimize their clinical use. Additionally, it addresses challenges in translating these findings into clinical treatments, such as improving study methodologies and addressing issues related to compound solubility, stability, and bioavailability.
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