1 citations
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October 2022 in “Annals of Translational Medicine” This study found that cucurbitacin cream reduced FGF18 levels and accelerated hair follicle transition to the anagen phase in mice, suggesting its potential as a treatment for hair regeneration.
May 2025 in “Antioxidants” This review highlights how natural products with antioxidant properties can modulate the Wnt signaling pathway, potentially influencing various pathological conditions such as cancer, stroke, and regenerative medicine. It also addresses controversies in the compounds' mechanisms across different models and suggests research directions for future studies.
23 citations
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November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
16 citations
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January 2016 in “Journal of Investigative Dermatology” This study found that IL-6 knockout mice exhibited increased wound-induced hair neogenesis compared to wild-type mice, likely due to enhanced STAT3 activation facilitated by compensatory cytokine activity.
11 citations
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November 2015 in “Experimental Dermatology” This study reported that IL-6/STAT3 signaling influences p63 isoform expression in keratinocytes and is involved in wound-induced hair follicle neogenesis, highlighting the interplay between immune and developmental pathways.