109 citations
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April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
6 citations
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November 2017 in “Journal of the Peripheral Nervous System” This study found that mercury chloride administration in rats led to decreased intraepidermal nerve fibers and increased Langerhans cells, suggesting small nerve fiber damage after mercury poisoning.
November 2024 in “Journal of Investigative Dermatology” In this study, UVB irradiation increased mast cell degranulation only when skin was innervated, suggesting that the interaction between mast cells and nerve fibres may exacerbate solar elastosis by promoting dysfunctional dermal elastic fiber accumulation, but further research is needed for confirmation.
9 citations
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June 2009 in “Cell Proliferation” This study found that Cream 1 effectively prevented UV radiation-induced nerve ending damage in human skin samples, unlike placebo and SPF15 creams.
4 citations
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July 2024 in “Pharmacology Research & Perspectives” In this phase 2a study of adults with alopecia areata, researchers observed that ritlecitinib treatment did not result in significant differences in brainstem auditory evoked potential changes or axonal swelling compared to placebo, suggesting the dog toxicity findings may not be clinically relevant in humans.