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GlossaryNeurogenic Inflammation

inflammation triggered by nerve-released chemicals causing redness and pain

Neurogenic inflammation is a type of inflammation triggered by the nervous system. It occurs when nerve fibers release certain chemicals, like substance P and calcitonin gene-related peptide (CGRP), which cause blood vessels to expand and immune cells to become activated, leading to redness, swelling, and pain. This process is often involved in conditions like migraines, asthma, and some skin disorders.

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research Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor

108 citations, July 2004 in “American Journal of Pathology”

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

research Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link

15 citations, January 2015 in “Skin Appendage Disorders”

Increased scalp sweating in frontal fibrosing alopecia may be linked to local skin inflammation.

research Substance P in Keratosis Follicularis Spinulosa Decalvans

4 citations, September 2015 in “JAAD case reports”

Substance P may play a role in the inflammation seen in keratosis follicularis spinulosa decalvans.

research Effects of Botulinum Toxin Type A on Histamine-Induced Itch and Vasomotor Responses in Human Skin

May 2008 in “Toxicon”

Botulinum toxin type A reduces itch and inflammation from histamine and may help treat certain skin conditions and hair loss.

research Neuroimmunology of Stress: Skin Takes Center Stage

375 citations, July 2006 in “Journal of Investigative Dermatology”

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

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community 7 months update - 1 mg fin, topical min

in Progress Pictures 736 upvotes 1 year ago

A user's 7-month progress using 1 mg finasteride and topical minoxidil, with no side effects from the finasteride, achieving baby hairs on the hairline and other positive results. Other users have discussed different treatments such as microneedling and supplements, providing advice and encouragement to the poster.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 8 months ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community How are you managing sex life when applying to topical minoxidil?

in Minoxidil 99 upvotes 1 year ago

User asks how to manage sex life while using topical minoxidil for hair loss. Responses suggest various strategies, including using finasteride, applying minoxidil before or after sex, and avoiding certain positions.

community Where do you guys get your stemoxydine from?

in Product 2 upvotes 2 weeks ago

Stemoxydine is available in L'Oréal's Serioxyl and Dercos Neogenic products, which can be found on Amazon, Ulta, or L'Oréal's website. A user is selling three bottles of L'Oréal Stemoxydine.

community Let's discuss experimental - RU58841, Dutasteride, and Others

6 upvotes 9 years ago

Discussing and researching different treatments for hair loss, including RU58841, Dutasteride, Spironolactone, Retin-A, Stemoxydine (Neogenic), Copper peptides, Superoxide Dismutase, NANO, and Eucapil.