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GlossaryNeuroinflammation

inflammation of nervous tissue involving immune cell activation

Neuroinflammation refers to the inflammation of the nervous tissue, which can occur in the brain or spinal cord. It is typically a response to infection, injury, or disease and involves the activation of immune cells within the central nervous system. This process can contribute to various neurological conditions, such as multiple sclerosis, Alzheimer's disease, and even some forms of alopecia, where the immune response may inadvertently target hair follicles.

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Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

37 citations, September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

research Direct Implantation of Hair-Follicle-Associated Pluripotent Stem Cells Repairs Intracerebral Hemorrhage and Reduces Neuroinflammation in Mouse Model

3 citations, January 2023 in “PloS one”

Implanting hair-follicle stem cells in mice brains helped repair brain bleeding and reduced brain inflammation.

research Anti-Amnesia-Like Effect of Pinus Densiflora Extract by Improving Apoptosis and Neuroinflammation in Trimethyltin-Induced ICR Mice

September 2023 in “International journal of molecular sciences”

Pinus densiflora extract may help improve memory and reduce brain inflammation.

research Protein Kinase C Downregulation Upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease

December 2020 in “Innovation in aging”

Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.

research Mechanisms Underlying Select Chemotherapeutic-Agent-Induced Neuroinflammation and Subsequent Neurodegeneration

21 citations, October 2018 in “European Journal of Pharmacology”

Chemotherapy can cause brain inflammation and damage, and understanding this process could help manage side effects.

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community Dutasteride actually has different half lives depending on dose

in Research/Science 37 upvotes 3 weeks ago

Dutasteride's half-life varies with dosage, and lower doses can be effective with fewer side effects compared to finasteride. Some users report different side effects with dutasteride and finasteride, and extreme dosages of dutasteride are unnecessary and potentially harmful.

community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 3 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 7 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR?

in Finasteride/Dutasteride 22 upvotes 7 months ago

Dutasteride and finasteride have similar risk profiles despite Dutasteride blocking more types of 5AR in the brain. Some users report no mood issues with either drug, and it is suggested that Dutasteride's larger molecular size may limit its ability to cross the blood-brain barrier.

community Is the DHT itch fact or fiction?

in Chat 16 upvotes 1 year ago

DHT itch's existence is debated, with some claiming it's real and others saying it's psychological. Finasteride, Ketoconazole shampoo, and addressing scalp conditions like dandruff or eczema may help reduce itchiness.