Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link

January 2015 in “ Skin Appendage Disorders ”

Matthew Harries, Sharon L. Wong, Paul Farrant

frontal fibrosing alopecia scarring hair loss frontal hairline recession eyebrow hair loss scalp sweating local skin inflammation axonal sweating reflex neuropeptides sweat gland secretion FFA hairline recession eyebrow loss sweating skin inflammation sweat reflex nerve peptides sweat secretion

TLDR Increased scalp sweating in frontal fibrosing alopecia may be linked to local skin inflammation.

The document discussed a study involving 11 women with Frontal Fibrosing Alopecia (FFA) and associated scalp sweating, proposing that neurogenic inflammation and neuropeptide signaling might link the two conditions. The study suggested that increased sweating could be more common among FFA patients than previously reported. Observations included improvements in symptoms with botulinum toxin and corticosteroid treatments. Histological findings indicated secondary changes due to localized inflammation. The authors recommended further research to quantify hyperhidrosis and explore neurogenic inflammation's role in FFA.

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