Frontal Fibrosing Alopecia and Increased Scalp Sweating: Is Neurogenic Inflammation the Common Link

    January 2015 in “ Skin Appendage Disorders ”
    Matthew Harries, Sharon L. Wong, Paul Farrant
    Studysummary This report discusses a series of patients with frontal fibrosing alopecia experiencing increased scalp sweating, which the authors hypothesize may be related to local skin inflammation affecting sweat gland activity.
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    Research cited in this study 14

    1. Incidental Syringomas of the Scalp in a Patient with Scarring Alopecia Case Reports in Dermatology · 2015
    2. Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients Journal of The American Academy of Dermatology · 2014
    3. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    4. Frontal Fibrosing Alopecia: A Review of 60 Cases Journal of The American Academy of Dermatology · 2012
    5. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011
    6. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    7. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    8. Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis British journal of dermatology/British journal of dermatology, Supplement · 2008
    9. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    10. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    11. Stress Exposure Modulates Peptidergic Innervation and Degranulates Mast Cells in Murine Skin Brain Behavior and Immunity · 2004
    12. Neurogenic Inflammation in Stress-Induced Termination of Murine Hair Growth Is Promoted by Nerve Growth Factor American Journal of Pathology · 2004
    13. Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris Journal of the American Academy of Dermatology · 1997
    14. Postmenopausal Frontal Fibrosing Alopecia Archives of Dermatology · 1994