Frontal Fibrosing Alopecia: Review of Recent Case Reports and Case Series in PubMed

    August 2018 in “ Journal der Deutschen Dermatologischen Gesellschaft ”
    Eva Maria Valesky, Manuela Denise Maier, Stefan Kippenberger, Roland Kaufmann, Markus Meißner
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    TLDR Most patients with frontal fibrosing alopecia are middle-aged women, often have thyroid disease, and some treatments can help stabilize the condition.
    The document reviewed 68 articles involving 932 patients with frontal fibrosing alopecia (FFA), a condition characterized by hairline recession and eyebrow loss, primarily affecting women (96.9%) around the age of 55.6 years at onset. The review found a high incidence of thyroid disease in FFA patients (31.4%) and noted the difficulty in distinguishing FFA from lichen planopilaris histologically. Treatments with 5α-reductase inhibitors, minoxidil, and corticosteroids showed some effectiveness in stabilizing the disease in 18 out of 41 patients and achieving regression in 3 patients. The study emphasized the need for controlled trials to develop effective treatments for FFA.
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