Postmenopausal Frontal Fibrosing Alopecia

    June 1994 in “ Archives of Dermatology ”
    Steven Kossard
    TLDR Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.
    The study examined six postmenopausal women who developed progressive frontal fibrosing alopecia, characterized by recession of the frontal hairline with perifollicular erythema and fibrosis extending to the temporal and parietal margins. Scalp biopsies revealed perifollicular fibrosis and lymphocytic inflammation, predominantly involving activated T-helper cells, similar to lichen planopilaris but without typical mucous membrane or skin lesions. Hormonal studies in five patients showed no elevated androgen levels. The findings suggested that this type of alopecia might be a distinct reaction pattern associated with postmenopausal changes rather than a form of lichen planopilaris.
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      in Research/Science  123 upvotes 4 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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      in Question  9 upvotes 8 years ago
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