Frontal Fibrosing Alopecia and Vitiligo: Coexistence or True Association

January 2016 in “ Skin Appendage Disorders ”

Alexander Katoulis, Konstantina Diamanti, Dimitrios Sgouros, Aikaterini Ι. Liakou, Antigoni Alevizou, Evangelia Bozi, Vasileia Damaskou, Ioannis Panayiotides, Dimitrios Rigopoulos

frontal fibrosing alopecia vitiligo immunologic events pathological processes

Studysummary This study observed two cases of frontal fibrosing alopecia developing on preexisting vitiligo, suggesting a potential causal link between the two conditions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the coexistence of frontal fibrosing alopecia (FFA) and vitiligo, conditions that are rarely reported together. In a retrospective analysis of 20 FFA cases over 14 months, 2 individuals, a 72-year-old woman and a 48-year-old man, exhibited FFA on preexisting vitiligo of the forehead. This anatomical colocalization suggested a potential causal link rather than a coincidental occurrence. The study proposed that interrelated immunologic events and pathological processes might underlie both conditions, indicating a possible association between FFA and vitiligo.

View this study on karger.com →

Discuss this study in the Community →

Research cited in this study

17 / 17 results

research Frontal Fibrosing Alopecia: A Retrospective Clinical Review of 62 Patients with Treatment Outcome and Long-Term Follow-Up

102 citations , April 2014 in “International Journal of Dermatology”

This study found that early intervention and treatment with intralesional triamcinolone acetonide may stabilize hairline recession in patients with frontal fibrosing alopecia, although further research is needed for definitive treatment guidelines.

research Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

339 citations , February 2014 in “Journal of The American Academy of Dermatology”

This study found that eyelash loss, facial papules, and body hair involvement were linked to severe frontal fibrosing alopecia, and antiandrogens were the most effective treatment.

research Frontal Fibrosing Alopecia in an African Man

13 citations , August 2013 in “International Journal of Dermatology”

Frontal fibrosing alopecia can affect African men and may be underdiagnosed.

research Frontal Fibrosing Alopecia: A Retrospective Review of 19 Patients Seen at Duke University

98 citations , January 2013 in “Journal of The American Academy of Dermatology”

This study reported that while various treatments for frontal fibrosing alopecia showed limited effectiveness, dutasteride most effectively stabilized the condition among patients at Duke University.

research Male Frontal Fibrosing Alopecia with Generalized Hair Loss

18 citations , November 2012 in “Australasian Journal of Dermatology”

This case report describes a 66-year-old man with frontal fibrosing alopecia, a rare lichen planopilaris variant, presenting with scarring alopecia at the hairline and extensive body hair loss.

research Frontal Fibrosing Alopecia: A Clinical Review of 36 Patients

159 citations , August 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, hydroxychloroquine significantly reduced signs and symptoms of frontal fibrosing alopecia after 6 months of treatment, with maximal benefits observed within the first 6 months.

research Frontal Fibrosing Alopecia in a Man: Results of Follicular Unit Test Grafting

53 citations , May 2010 in “Dermatologic Surgery”

This article appears to be a table of contents or navigation page for a journal, not presenting any new findings or research results.

research Treatment of Postmenopausal Frontal Fibrosing Alopecia with Oral Dutasteride

64 citations , June 2009 in “Journal of The American Academy of Dermatology”

This article discusses frontal fibrosing alopecia, noting potential connections to lichen planopilaris, but reports no new clinical findings.

research Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis

155 citations , September 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

This study observed that frontal fibrosing alopecia predominantly affects postmenopausal women, can be associated with lichen planus, and may lead to progressive hairline recession, though this progression is not consistent in all cases.

research Frontal Fibrosing Alopecia: Diagnostic and Therapeutic Assessment

54 citations , November 2007 in “Actas Dermo-Sifiliográficas”

Early diagnosis of frontal fibrosing alopecia is crucial to prevent permanent hair loss.

research Diagnostic and Therapeutic Assessment of Frontal Fibrosing Alopecia

16 citations , January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

This review discusses frontal fibrosing alopecia and reports no clinical results; the authors note that no therapeutic options tested, including corticosteroids, finasteride, and minoxidil, have shown clear benefits.

research Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study

126 citations , April 2006 in “International Journal of Dermatology”

This study found that frontal fibrosing alopecia and lichen planopilaris have similar histopathological features, but FFA exhibits more prominent apoptosis and less inflammation with spared interfollicular epidermis.

research Frontal Fibrosing Alopecia Developing After Hair Transplantation for Androgenetic Alopecia

64 citations , January 2005 in “International Journal of Dermatology”

This report discusses cases of frontal fibrosing alopecia developing after hair transplantation for androgenetic alopecia, without presenting new clinical findings.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations , December 2004 in “Journal of The American Academy of Dermatology”

This study observed that frontal fibrosing alopecia in postmenopausal women involves selective follicular inflammation, and finasteride treatment may slow disease progression, suggesting a potential androgen-related component.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

This study reports that progressive frontal fibrosing alopecia, a distinct and gradually stabilizing form of lichen planopilaris affecting elderly women and often involving eyebrow hair loss, lacks effective treatments.

research Postmenopausal Frontal Fibrosing Alopecia

325 citations , June 1994 in “Archives of Dermatology”

This study observed that progressive frontal recession in postmenopausal women may exhibit features of fibrosing alopecia, suggesting a distinct reaction pattern from typical lichen planopilaris.

research Postmenopausal Frontal Fibrosing Alopecia: Scarring Alopecia in a Pattern Distribution

332 citations , June 1994 in “Archives of Dermatology”

This study found that progressive frontal hairline recession in postmenopausal women may exhibit features similar to fibrosing alopecia, with histologic similarities to lichen planopilaris but lacking lesions of lichen planus.