Frontal Fibrosing Alopecia: Diagnostic and Therapeutic Assessment

November 2007 in “ Actas Dermo-Sifiliográficas ”

D. Moreno‐Ramírez, L. Ferrándiz, F.M. Camacho

frontal fibrosing alopecia primary cicatricial alopecia lymphocytic inflammation chronic cutaneous lupus erythematosus lichen planopilaris anti-inflammatory medications immunosuppressants

TLDR Early diagnosis of frontal fibrosing alopecia is crucial to prevent permanent hair loss.

The document discussed frontal fibrosing alopecia (FFA), a type of primary cicatricial alopecia characterized by lymphocytic inflammation leading to permanent hair loss. It was associated with conditions like chronic cutaneous lupus erythematosus and lichen planopilaris. The study highlighted the diagnostic challenges and therapeutic approaches for FFA, emphasizing the importance of early diagnosis to prevent irreversible hair loss. Treatment options at the time included anti-inflammatory medications and immunosuppressants, although their effectiveness varied. The document underscored the need for further research to better understand the pathogenesis and improve treatment outcomes for patients with FFA.

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Research cited in this study

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research Frontal Fibrosing Alopecia Versus Lichen Planopilaris: A Clinicopathological Study

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The conclusion is that FFA and LPP have similar scalp biopsy features, making them hard to distinguish histologically, and FFA may be a specific kind of scarring hair loss.

research Frontal Fibrosing Alopecia: A Survey in 16 Patients

123 citations , August 2005 in “Journal of the European Academy of Dermatology and Venereology”

The study found that Frontal Fibrosing Alopecia affects a broader age range of women and early treatment can help stop hair loss.

research Frontal Fibrosing Alopecia in Postmenopausal Women

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Some postmenopausal women with frontal fibrosing alopecia stopped losing hair with finasteride treatment, hinting at a possible hormonal cause.

research Postmenopausal Frontal Fibrosing Alopecia

57 citations , January 2003 in “Clinical and experimental dermatology”

Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Postmenopausal Frontal Fibrosing Alopecia: Scarring Alopecia in a Pattern Distribution

332 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.

research Postmenopausal Frontal Fibrosing Alopecia

325 citations , June 1994 in “Archives of Dermatology”

Postmenopausal frontal fibrosing alopecia may be a unique condition linked to postmenopausal changes.

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in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Testosterone and hair loss seeming irrelevance

in Research/Science 81 upvotes 2 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 4 weeks ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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Male pattern baldness is linked to health risks and should be treated medically. Finasteride is effective and should be insurance-covered.

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in Research/Science 3 years ago

Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.

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