Frontal Fibrosing Alopecia: A Multicenter Review of 355 Patients

    February 2014 in “ Journal of The American Academy of Dermatology ”
    Sergio Vañó‐Galván, Ana María Molina-Ruiz, C. Serrano-Falcón, Salvador Arias‐Santiago, Ana Rita Rodrigues-Barata, Gloria Garnacho‐Saucedo, A. Martorell, Pablo Fernández‐Crehuet, Ramón Grimalt, Beatriz Aranegui, Emiliano Grillo, B. Díaz-Ley, R. Salido, Sivia Pérez-Gala, Salvio Serrano, J.C. Moreno, Pedro Jaén, Francisco Camacho
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    TLDR Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
    In the 2014 multicenter retrospective study of 355 patients with frontal fibrosing alopecia (FFA), researchers found that the condition predominantly affects postmenopausal women, with a mean age of 61 years, but can also occur in men and premenopausal women. Severe FFA, which involves significant recession of the frontotemporal hairline, was present in 37% of patients and was associated with eyelash loss, facial papules, and body hair involvement. Antiandrogens like finasteride and dutasteride were given to 31% of patients, with 47% showing improvement and 53% experiencing stabilization of the disease. The study suggests a hormonal role in FFA's pathogenesis, indicated by the high incidence of early menopause among patients and the response to antiandrogenic drugs. Other treatments had variable results, and the study highlights the potential for FFA to affect a broader demographic than previously thought.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Diffuse thinning is so brutal.

      in Styling  72 upvotes 1 year ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 3 months ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community M18 - 7 Months on topical fin + min Not working for me

      in Finasteride/Dutasteride  84 upvotes 2 days ago
      Topical finasteride and minoxidil are not effective for the user, who is considering switching to oral treatments like finasteride or dutasteride. Many suggest oral medications are more effective, and some recommend additional treatments like microneedling and other topical solutions.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

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