Diphencyprone Induced Vitiligo: A Case Report

This case report described two patients who developed vitiligo after being treated with diphencyprone (DPCP) for alopecia areata (AA). A 37-year-old man and a 42-year-old woman, both with no personal or family history of vitiligo, experienced vitiligo patches distant from the DPCP application sites. The male patient showed a positive patch test, suggesting DPCP's direct role in causing vitiligo. The report emphasized the unpredictability of vitiligo development with DPCP treatment and the importance of informing patients about this potential adverse effect. Despite the successful regrowth of hair, the persistence of depigmentation led to the discontinuation of DPCP therapy.